| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKAP11 | GSK3B | ENSP00000025301 | ENSP00000324806 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | 0.787 |
| AKAP11 | IRX1 | ENSP00000025301 | ENSP00000305244 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | iroquois homeobox 1 | 0.643 |
| AKAP11 | IRX2 | ENSP00000025301 | ENSP00000307006 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | iroquois homeobox 2 | 0.683 |
| AKAP11 | IRX3 | ENSP00000025301 | ENSP00000331608 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | iroquois homeobox 3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells (By similarity) | 0.742 |
| AKAP11 | PPP1CA | ENSP00000025301 | ENSP00000326031 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | 0.804 |
| AKAP11 | PPP1CC | ENSP00000025301 | ENSP00000335084 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] | 0.963 |
| AKAP11 | PRKACB | ENSP00000025301 | ENSP00000359719 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | protein kinase, cAMP-dependent, catalytic, beta | 0.738 |
| AKAP11 | PRKAR2A | ENSP00000025301 | ENSP00000265563 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.964 |
| AKAP11 | PRKAR2B | ENSP00000025301 | ENSP00000265717 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.622 |
| AKAP11 | TBC1D1 | ENSP00000025301 | ENSP00000261439 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.680 |
| GSK3B | AKAP11 | ENSP00000324806 | ENSP00000025301 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | 0.787 |
| GSK3B | PPP1CA | ENSP00000324806 | ENSP00000326031 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | protein phosphatase 1, catalytic subunit, alpha isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent p [...] | 0.902 |
| GSK3B | PPP1CC | ENSP00000324806 | ENSP00000335084 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | protein phosphatase 1, catalytic subunit, gamma isozyme; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca [...] | 0.964 |
| GSK3B | PRKACB | ENSP00000324806 | ENSP00000359719 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | protein kinase, cAMP-dependent, catalytic, beta | 0.897 |
| GSK3B | PRKAR2A | ENSP00000324806 | ENSP00000265563 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.895 |
| GSK3B | PRKAR2B | ENSP00000324806 | ENSP00000265717 | glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.694 |
| IRX1 | AKAP11 | ENSP00000305244 | ENSP00000025301 | iroquois homeobox 1 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | 0.643 |
| IRX1 | TBC1D1 | ENSP00000305244 | ENSP00000261439 | iroquois homeobox 1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.493 |
| IRX2 | AKAP11 | ENSP00000307006 | ENSP00000025301 | iroquois homeobox 2 | A kinase (PRKA) anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them | 0.683 |
| IRX2 | TBC1D1 | ENSP00000307006 | ENSP00000261439 | iroquois homeobox 2 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity) | 0.563 |
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