| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARG1 | ARG2 | ENSP00000357066 | ENSP00000261783 | arginase, liver | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | 0.590 |
| ARG1 | ASL | ENSP00000357066 | ENSP00000307188 | arginase, liver | argininosuccinate lyase | 0.966 |
| ARG1 | ASS1 | ENSP00000357066 | ENSP00000253004 | arginase, liver | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.651 |
| ARG1 | ENSG00000114786 | ENSP00000357066 | ENSP00000420487 | arginase, liver | ABHD14A-ACY1 readthrough (non-protein coding) | 0.912 |
| ARG1 | NAGS | ENSP00000357066 | ENSP00000293404 | arginase, liver | N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity | 0.575 |
| ARG1 | OAT | ENSP00000357066 | ENSP00000357838 | arginase, liver | ornithine aminotransferase | 0.982 |
| ARG1 | ODC1 | ENSP00000357066 | ENSP00000234111 | arginase, liver | ornithine decarboxylase 1 | 0.968 |
| ARG1 | OTC | ENSP00000357066 | ENSP00000039007 | arginase, liver | ornithine carbamoyltransferase | 0.981 |
| ARG2 | ARG1 | ENSP00000261783 | ENSP00000357066 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | arginase, liver | 0.590 |
| ARG2 | ASL | ENSP00000261783 | ENSP00000307188 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | argininosuccinate lyase | 0.542 |
| ARG2 | ASS1 | ENSP00000261783 | ENSP00000253004 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.468 |
| ARG2 | ENSG00000114786 | ENSP00000261783 | ENSP00000420487 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ABHD14A-ACY1 readthrough (non-protein coding) | 0.912 |
| ARG2 | NAGS | ENSP00000261783 | ENSP00000293404 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity | 0.522 |
| ARG2 | OAT | ENSP00000261783 | ENSP00000357838 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ornithine aminotransferase | 0.986 |
| ARG2 | ODC1 | ENSP00000261783 | ENSP00000234111 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ornithine decarboxylase 1 | 0.959 |
| ARG2 | OTC | ENSP00000261783 | ENSP00000039007 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ornithine carbamoyltransferase | 0.964 |
| ASL | ARG1 | ENSP00000307188 | ENSP00000357066 | argininosuccinate lyase | arginase, liver | 0.966 |
| ASL | ARG2 | ENSP00000307188 | ENSP00000261783 | argininosuccinate lyase | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | 0.542 |
| ASL | ASS1 | ENSP00000307188 | ENSP00000253004 | argininosuccinate lyase | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.999 |
| ASL | CAD | ENSP00000307188 | ENSP00000264705 | argininosuccinate lyase | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.928 |
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