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CLIC5 CLIC5 SLC26A6 SLC26A6 CNGA2 CNGA2 ANO1 ANO1 CLCN1 CLCN1 BEST2 BEST2 ANO6 ANO6 CFTR CFTR ANO2 ANO2 TTYH2 TTYH2 TTYH3 TTYH3
"BEST2" - bestrophin 2 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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Score
BEST2bestrophin 2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (509 aa)    
Predicted Functional Partners:
ANO1
anoctamin 1, calcium activated chloride channel; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development (986 aa)
          score_image score_image   0.823
ANO2
anoctamin 2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina (998 aa)
          score_image score_image   0.793
CNGA2
cyclic nucleotide gated channel alpha 2; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons (664 aa)
            score_image   0.747
TTYH3
tweety homolog 3 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (523 aa)
          score_image score_image   0.735
ANO6
anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (931 aa)
          score_image score_image   0.693
CLCN1
chloride channel, voltage-sensitive 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport (988 aa)
          score_image score_image   0.689
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
          score_image score_image   0.678
TTYH2
tweety homolog 2 (Drosophila); Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (534 aa)
          score_image score_image   0.628
SLC26A6
solute carrier family 26, member 6; Does not seem to be involved in anion transport (759 aa)
          score_image score_image   0.611
CLIC5
chloride intracellular channel 5; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Required for normal formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (410 aa)
          score_image score_image   0.607
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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