ZPBP protein (Homo sapiens) - STRING network view

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ZPBP

zona pellucida binding protein; May be implicated in gamete interaction during fertilization (351 aa)

Predicted Functional Partners:

ZP2

0.781

SPA17

0.757

GRB7

0.741

GRB10

0.610

IKZF3

0.609

SPAM1

0.566

ACR

0.563

ACRBP

0.534

CCDC54

0.534

ANKRD5

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACR	ACRBP	ENSP00000216139	ENSP00000229243	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	0.581
ACR	SPAM1	ENSP00000216139	ENSP00000345849	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid	0.659
ACR	ZP2	ENSP00000216139	ENSP00000219593	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	zona pellucida glycoprotein 2 (sperm receptor); The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor	0.834
ACR	ZPBP	ENSP00000216139	ENSP00000046087	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.563
ACRBP	ACR	ENSP00000229243	ENSP00000216139	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome	0.581
ACRBP	ANKRD5	ENSP00000229243	ENSP00000367631	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	ankyrin repeat domain 5	0.416
ACRBP	SPA17	ENSP00000229243	ENSP00000227135	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	sperm autoantigenic protein 17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)	0.659
ACRBP	SPAM1	ENSP00000229243	ENSP00000345849	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid	0.418
ACRBP	ZPBP	ENSP00000229243	ENSP00000046087	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.534
ANKRD5	ACRBP	ENSP00000367631	ENSP00000229243	ankyrin repeat domain 5	acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity)	0.416
ANKRD5	ZPBP	ENSP00000367631	ENSP00000046087	ankyrin repeat domain 5	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.529
CCDC54	SPA17	ENSP00000261058	ENSP00000227135	coiled-coil domain containing 54	sperm autoantigenic protein 17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)	0.514
CCDC54	ZPBP	ENSP00000261058	ENSP00000046087	coiled-coil domain containing 54	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.534
GRB10	GRB7	ENSP00000381793	ENSP00000403459	growth factor receptor-bound protein 10	growth factor receptor-bound protein 7	0.903
GRB10	ZPBP	ENSP00000381793	ENSP00000046087	growth factor receptor-bound protein 10	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.610
GRB7	GRB10	ENSP00000403459	ENSP00000381793	growth factor receptor-bound protein 7	growth factor receptor-bound protein 10	0.903
GRB7	IKZF3	ENSP00000403459	ENSP00000344544	growth factor receptor-bound protein 7	IKAROS family zinc finger 3 (Aiolos)	0.446
GRB7	ZPBP	ENSP00000403459	ENSP00000046087	growth factor receptor-bound protein 7	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.741
IKZF3	GRB7	ENSP00000344544	ENSP00000403459	IKAROS family zinc finger 3 (Aiolos)	growth factor receptor-bound protein 7	0.446
IKZF3	ZPBP	ENSP00000344544	ENSP00000046087	IKAROS family zinc finger 3 (Aiolos)	zona pellucida binding protein; May be implicated in gamete interaction during fertilization	0.609

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