node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DCN | EGFR | ENSP00000052754 | ENSP00000275493 | decorin; May affect the rate of fibrils formation | epidermal growth factor receptor | 0.996 |
DCN | FBN1 | ENSP00000052754 | ENSP00000325527 | decorin; May affect the rate of fibrils formation | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | 0.965 |
DCN | HSPG2 | ENSP00000052754 | ENSP00000363827 | decorin; May affect the rate of fibrils formation | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.974 |
DCN | IGF1 | ENSP00000052754 | ENSP00000302665 | decorin; May affect the rate of fibrils formation | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | 0.973 |
DCN | MET | ENSP00000052754 | ENSP00000317272 | decorin; May affect the rate of fibrils formation | met proto-oncogene (hepatocyte growth factor receptor); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 [...] | 0.986 |
DCN | MMP2 | ENSP00000052754 | ENSP00000219070 | decorin; May affect the rate of fibrils formation | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.986 |
DCN | MMP7 | ENSP00000052754 | ENSP00000260227 | decorin; May affect the rate of fibrils formation | matrix metallopeptidase 7 (matrilysin, uterine); Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase | 0.973 |
DCN | TGFB1 | ENSP00000052754 | ENSP00000221930 | decorin; May affect the rate of fibrils formation | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.999 |
DCN | TGFB2 | ENSP00000052754 | ENSP00000355896 | decorin; May affect the rate of fibrils formation | transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth | 0.970 |
DCN | VCAN | ENSP00000052754 | ENSP00000265077 | decorin; May affect the rate of fibrils formation | versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid | 0.986 |
EGFR | DCN | ENSP00000275493 | ENSP00000052754 | epidermal growth factor receptor | decorin; May affect the rate of fibrils formation | 0.996 |
EGFR | HSPG2 | ENSP00000275493 | ENSP00000363827 | epidermal growth factor receptor | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.978 |
EGFR | IGF1 | ENSP00000275493 | ENSP00000302665 | epidermal growth factor receptor | insulin-like growth factor 1 (somatomedin C); The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake | 0.987 |
EGFR | MET | ENSP00000275493 | ENSP00000317272 | epidermal growth factor receptor | met proto-oncogene (hepatocyte growth factor receptor); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 [...] | 0.972 |
EGFR | MMP2 | ENSP00000275493 | ENSP00000219070 | epidermal growth factor receptor | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.730 |
EGFR | MMP7 | ENSP00000275493 | ENSP00000260227 | epidermal growth factor receptor | matrix metallopeptidase 7 (matrilysin, uterine); Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase | 0.739 |
EGFR | TGFB1 | ENSP00000275493 | ENSP00000221930 | epidermal growth factor receptor | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.699 |
EGFR | TGFB2 | ENSP00000275493 | ENSP00000355896 | epidermal growth factor receptor | transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth | 0.478 |
FBN1 | DCN | ENSP00000325527 | ENSP00000052754 | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | decorin; May affect the rate of fibrils formation | 0.965 |
FBN1 | HSPG2 | ENSP00000325527 | ENSP00000363827 | fibrillin 1; Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1- containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.952 |