THAP3 protein (Homo sapiens) - STRING network view

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THAP3

THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (239 aa)

Predicted Functional Partners:

HCFC1

0.925

PRKRIR

0.802

THAP11

0.759

OGT

0.615

CCDC137

0.581

THAP10

0.580

TMEM104

0.566

THAP6

0.538

CDRT4

0.538

ZNF251

0.512

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC137	CDRT4	ENSP00000329360	ENSP00000310031	coiled-coil domain containing 137	CMT1A duplicated region transcript 4	0.580
CCDC137	THAP3	ENSP00000329360	ENSP00000054650	coiled-coil domain containing 137	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.581
CCDC137	TMEM104	ENSP00000329360	ENSP00000334849	coiled-coil domain containing 137	transmembrane protein 104	0.584
CDRT4	CCDC137	ENSP00000310031	ENSP00000329360	CMT1A duplicated region transcript 4	coiled-coil domain containing 137	0.580
CDRT4	THAP3	ENSP00000310031	ENSP00000054650	CMT1A duplicated region transcript 4	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.538
CDRT4	TMEM104	ENSP00000310031	ENSP00000334849	CMT1A duplicated region transcript 4	transmembrane protein 104	0.570
HCFC1	OGT	ENSP00000309555	ENSP00000362824	host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...]	O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...]	0.999
HCFC1	THAP11	ENSP00000309555	ENSP00000304689	host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...]	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	0.912
HCFC1	THAP3	ENSP00000309555	ENSP00000054650	host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...]	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.925
OGT	HCFC1	ENSP00000362824	ENSP00000309555	O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...]	host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...]	0.999
OGT	THAP3	ENSP00000362824	ENSP00000054650	O-linked N-acetylglucosamine (GlcNAc) transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, PFKL, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glyc [...]	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.615
PRKRIR	THAP11	ENSP00000260045	ENSP00000304689	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	0.758
PRKRIR	THAP3	ENSP00000260045	ENSP00000054650	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.802
THAP10	THAP11	ENSP00000249861	ENSP00000304689	THAP domain containing 10	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	0.416
THAP10	THAP3	ENSP00000249861	ENSP00000054650	THAP domain containing 10	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.580
THAP10	THAP6	ENSP00000249861	ENSP00000309007	THAP domain containing 10	THAP domain containing 6	0.649
THAP11	HCFC1	ENSP00000304689	ENSP00000309555	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 ’Lys-4’ methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional a [...]	0.912
THAP11	PRKRIR	ENSP00000304689	ENSP00000260045	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth	0.758
THAP11	THAP10	ENSP00000304689	ENSP00000249861	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	THAP domain containing 10	0.416
THAP11	THAP3	ENSP00000304689	ENSP00000054650	THAP domain containing 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity)	THAP domain containing, apoptosis associated protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1	0.759

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