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STRINGSTRING
CLDN16 CLDN16 INADL INADL MPDZ MPDZ CLDN23 CLDN23 CLDN5 CLDN5 CLDN11 CLDN11 TJP3 TJP3 CLDN22 CLDN22 CLDN17 CLDN17 TJP2 TJP2 TJP1 TJP1
"CLDN11" - claudin 11 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLDN11claudin 11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (207 aa)    
Predicted Functional Partners:
CLDN23
claudin 23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (292 aa)
          score_image score_image   0.933
TJP1
tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (1748 aa)
          score_image score_image   0.911
CLDN17
claudin 17; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (224 aa)
          score_image score_image   0.908
TJP2
tight junction protein 2 (1221 aa)
          score_image score_image   0.902
TJP3
tight junction protein 3 (952 aa)
          score_image score_image   0.895
MPDZ
multiple PDZ domain protein (2041 aa)
          score_image score_image   0.882
CLDN22
claudin 22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity) (220 aa)
          score_image score_image   0.857
CLDN16
claudin 16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (305 aa)
          score_image score_image score_image 0.847
INADL
InaD-like (Drosophila) (1801 aa)
          score_image score_image   0.846
CLDN5
claudin 5; Plays a major role in tight junction-specific obliteration of the intercellular space (By similarity) (303 aa)
          score_image score_image score_image 0.846
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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