node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GRWD1 | RELT | ENSP00000253237 | ENSP00000064780 | glutamate-rich WD repeat containing 1 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | 0.469 |
GRWD1 | SERAC1 | ENSP00000253237 | ENSP00000356071 | glutamate-rich WD repeat containing 1 | serine active site containing 1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36-1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway | 0.640 |
LTBR | RELT | ENSP00000228918 | ENSP00000064780 | lymphotoxin beta receptor (TNFR superfamily, member 3); Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | 0.440 |
LTBR | TRAF1 | ENSP00000228918 | ENSP00000362994 | lymphotoxin beta receptor (TNFR superfamily, member 3); Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.737 |
OXSR1 | RELL1 | ENSP00000311713 | ENSP00000313385 | oxidative-stress responsive 1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton | RELT-like 1 | 0.923 |
OXSR1 | RELT | ENSP00000311713 | ENSP00000064780 | oxidative-stress responsive 1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | 0.961 |
RELL1 | OXSR1 | ENSP00000313385 | ENSP00000311713 | RELT-like 1 | oxidative-stress responsive 1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton | 0.923 |
RELL1 | RELT | ENSP00000313385 | ENSP00000064780 | RELT-like 1 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | 0.674 |
RELL1 | TRAF1 | ENSP00000313385 | ENSP00000362994 | RELT-like 1 | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.400 |
RELT | GRWD1 | ENSP00000064780 | ENSP00000253237 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | glutamate-rich WD repeat containing 1 | 0.469 |
RELT | LTBR | ENSP00000064780 | ENSP00000228918 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | lymphotoxin beta receptor (TNFR superfamily, member 3); Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs | 0.440 |
RELT | OXSR1 | ENSP00000064780 | ENSP00000311713 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | oxidative-stress responsive 1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton | 0.961 |
RELT | RELL1 | ENSP00000064780 | ENSP00000313385 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | RELT-like 1 | 0.674 |
RELT | SERAC1 | ENSP00000064780 | ENSP00000356071 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | serine active site containing 1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36-1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway | 0.529 |
RELT | STK39 | ENSP00000064780 | ENSP00000348278 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | serine threonine kinase 39; May act as a mediator of stress-activated signals | 0.927 |
RELT | TNFRSF19 | ENSP00000064780 | ENSP00000371693 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | tumor necrosis factor receptor superfamily, member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death | 0.513 |
RELT | TNFRSF4 | ENSP00000064780 | ENSP00000368538 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34 | 0.439 |
RELT | TP63 | ENSP00000064780 | ENSP00000264731 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | tumor protein p63; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.462 |
RELT | TRAF1 | ENSP00000064780 | ENSP00000362994 | RELT tumor necrosis factor receptor; Mediates activation of NF-kappa-B. May play a role in T- cell activation | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.944 |
SERAC1 | GRWD1 | ENSP00000356071 | ENSP00000253237 | serine active site containing 1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation- acylation reaction to produce phosphatidylglycerol-36-1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway | glutamate-rich WD repeat containing 1 | 0.640 |