node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLP2 | APP | ENSP00000263574 | ENSP00000284981 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | amyloid beta (A4) precursor protein | 0.595 |
APLP2 | APPBP2 | ENSP00000263574 | ENSP00000083182 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.724 |
APLP2 | KIF5A | ENSP00000263574 | ENSP00000408979 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | 0.528 |
APLP2 | KIF5B | ENSP00000263574 | ENSP00000307078 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | 0.532 |
APLP2 | KIF5C | ENSP00000263574 | ENSP00000393379 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin family member 5C | 0.528 |
APLP2 | KLC1 | ENSP00000263574 | ENSP00000414982 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | kinesin light chain 1 | 0.853 |
APLP2 | UBC | ENSP00000263574 | ENSP00000344818 | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | ubiquitin C | 0.966 |
APP | APLP2 | ENSP00000284981 | ENSP00000263574 | amyloid beta (A4) precursor protein | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.595 |
APP | APPBP2 | ENSP00000284981 | ENSP00000083182 | amyloid beta (A4) precursor protein | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.948 |
APP | KIF5A | ENSP00000284981 | ENSP00000408979 | amyloid beta (A4) precursor protein | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | 0.609 |
APP | KIF5B | ENSP00000284981 | ENSP00000307078 | amyloid beta (A4) precursor protein | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | 0.640 |
APP | KIF5C | ENSP00000284981 | ENSP00000393379 | amyloid beta (A4) precursor protein | kinesin family member 5C | 0.555 |
APP | KLC1 | ENSP00000284981 | ENSP00000414982 | amyloid beta (A4) precursor protein | kinesin light chain 1 | 0.987 |
APP | UBC | ENSP00000284981 | ENSP00000344818 | amyloid beta (A4) precursor protein | ubiquitin C | 0.991 |
APPBP2 | APLP2 | ENSP00000083182 | ENSP00000263574 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.724 |
APPBP2 | APP | ENSP00000083182 | ENSP00000284981 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | amyloid beta (A4) precursor protein | 0.948 |
APPBP2 | AR | ENSP00000083182 | ENSP00000363822 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.960 |
APPBP2 | BCAS3 | ENSP00000083182 | ENSP00000375067 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | breast carcinoma amplified sequence 3 | 0.738 |
APPBP2 | KIF5A | ENSP00000083182 | ENSP00000408979 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | kinesin family member 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL) (By similarity) | 0.762 |
APPBP2 | KIF5B | ENSP00000083182 | ENSP00000307078 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | kinesin family member 5B; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes (By similarity) | 0.762 |