| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DGCR6 | GSC2 | ENSP00000331681 | ENSP00000086933 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | 0.464 |
| DGCR6 | RTDR1 | ENSP00000331681 | ENSP00000216036 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | rhabdoid tumor deletion region gene 1 | 0.453 |
| DGCR6 | UFD1L | ENSP00000331681 | ENSP00000263202 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | ubiquitin fusion degradation 1 like (yeast); Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures | 0.732 |
| DGCR6 | USP18 | ENSP00000331681 | ENSP00000215794 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | ubiquitin specific peptidase 18; Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms | 0.471 |
| FOXM1 | GSC2 | ENSP00000342307 | ENSP00000086933 | forkhead box M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | 0.444 |
| FOXM1 | SRF | ENSP00000342307 | ENSP00000265354 | forkhead box M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.618 |
| FOXO1 | GSC2 | ENSP00000368880 | ENSP00000086933 | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | 0.434 |
| FOXO1 | SRF | ENSP00000368880 | ENSP00000265354 | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.734 |
| GSC2 | DGCR6 | ENSP00000086933 | ENSP00000331681 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches | 0.464 |
| GSC2 | FOXM1 | ENSP00000086933 | ENSP00000342307 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | forkhead box M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response | 0.444 |
| GSC2 | FOXO1 | ENSP00000086933 | ENSP00000368880 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | forkhead box O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5’-TT[G/A]TTTTG-3’ and the related Daf-16 family binding element (DBE) with consensus sequence 5’- TT[G/A]TTTAC-3’. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGL [...] | 0.434 |
| GSC2 | NAGA | ENSP00000086933 | ENSP00000379680 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | N-acetylgalactosaminidase, alpha-; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids | 0.519 |
| GSC2 | RAB36 | ENSP00000086933 | ENSP00000263116 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | RAB36, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.632 |
| GSC2 | RNF4 | ENSP00000086933 | ENSP00000315212 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | ring finger protein 4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates ’Lys-6’-, ’Lys-11’-, ’Lys-48’- and ’Lys-63’-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses t [...] | 0.611 |
| GSC2 | RTDR1 | ENSP00000086933 | ENSP00000216036 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | rhabdoid tumor deletion region gene 1 | 0.608 |
| GSC2 | SRF | ENSP00000086933 | ENSP00000265354 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation | 0.696 |
| GSC2 | UFD1L | ENSP00000086933 | ENSP00000263202 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | ubiquitin fusion degradation 1 like (yeast); Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures | 0.504 |
| GSC2 | USP18 | ENSP00000086933 | ENSP00000215794 | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | ubiquitin specific peptidase 18; Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms | 0.489 |
| NAGA | GSC2 | ENSP00000379680 | ENSP00000086933 | N-acetylgalactosaminidase, alpha-; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids | goosecoid homeobox 2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC | 0.519 |
| NAGA | RTDR1 | ENSP00000379680 | ENSP00000216036 | N-acetylgalactosaminidase, alpha-; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids | rhabdoid tumor deletion region gene 1 | 0.451 |
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