GPKOW protein (Homo sapiens) - STRING network view

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Score

GPKOW

G patch domain and KOW motifs (476 aa)

Predicted Functional Partners:

SLU7

0.781

FAAH2

0.732

EBP

0.720

MFAP1

0.705

KLHL18

0.697

PPIL4

0.612

RGN

0.600

BGN

0.588

C20orf72

0.579

DHX38

0.575

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BGN	FAAH2	ENSP00000327336	ENSP00000364035	biglycan; May be involved in collagen fiber assembly (By similarity)	fatty acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates	0.442
BGN	GPKOW	ENSP00000327336	ENSP00000156109	biglycan; May be involved in collagen fiber assembly (By similarity)	G patch domain and KOW motifs	0.588
C20orf72	GPKOW	ENSP00000366939	ENSP00000156109	chromosome 20 open reading frame 72; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5’-3’ exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair	G patch domain and KOW motifs	0.579
DHX38	GPKOW	ENSP00000268482	ENSP00000156109	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	G patch domain and KOW motifs	0.575
DHX38	MFAP1	ENSP00000268482	ENSP00000267812	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.711
DHX38	SLU7	ENSP00000268482	ENSP00000297151	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation	0.998
EBP	GPKOW	ENSP00000417052	ENSP00000156109	emopamil binding protein (sterol isomerase); Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers	G patch domain and KOW motifs	0.720
FAAH2	BGN	ENSP00000364035	ENSP00000327336	fatty acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates	biglycan; May be involved in collagen fiber assembly (By similarity)	0.442
FAAH2	GPKOW	ENSP00000364035	ENSP00000156109	fatty acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates	G patch domain and KOW motifs	0.732
FAAH2	RGN	ENSP00000364035	ENSP00000253303	fatty acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates	regucalcin (senescence marker protein-30); Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)	0.520
GPKOW	BGN	ENSP00000156109	ENSP00000327336	G patch domain and KOW motifs	biglycan; May be involved in collagen fiber assembly (By similarity)	0.588
GPKOW	C20orf72	ENSP00000156109	ENSP00000366939	G patch domain and KOW motifs	chromosome 20 open reading frame 72; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5’-3’ exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair	0.579
GPKOW	DHX38	ENSP00000156109	ENSP00000268482	G patch domain and KOW motifs	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	0.575
GPKOW	EBP	ENSP00000156109	ENSP00000417052	G patch domain and KOW motifs	emopamil binding protein (sterol isomerase); Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers	0.720
GPKOW	FAAH2	ENSP00000156109	ENSP00000364035	G patch domain and KOW motifs	fatty acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates	0.732
GPKOW	KLHL18	ENSP00000156109	ENSP00000232766	G patch domain and KOW motifs	kelch-like 18 (Drosophila)	0.697
GPKOW	MFAP1	ENSP00000156109	ENSP00000267812	G patch domain and KOW motifs	microfibrillar-associated protein 1; Component of the elastin-associated microfibrils	0.705
GPKOW	PPIL4	ENSP00000156109	ENSP00000253329	G patch domain and KOW motifs	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	0.612
GPKOW	RGN	ENSP00000156109	ENSP00000253303	G patch domain and KOW motifs	regucalcin (senescence marker protein-30); Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity)	0.600
GPKOW	SLU7	ENSP00000156109	ENSP00000297151	G patch domain and KOW motifs	SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation	0.781

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