node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C4orf27 | FAM110B | ENSP00000406598 | ENSP00000355204 | chromosome 4 open reading frame 27 | family with sequence similarity 110, member B; May be involved in tumor progression | 0.583 |
C4orf27 | ISOC1 | ENSP00000406598 | ENSP00000173527 | chromosome 4 open reading frame 27 | isochorismatase domain containing 1 | 0.559 |
C4orf27 | SPEF2 | ENSP00000406598 | ENSP00000348314 | chromosome 4 open reading frame 27 | sperm flagellar 2; Required for correct axoneme development (By similarity) | 0.579 |
C4orf27 | UFSP2 | ENSP00000406598 | ENSP00000264689 | chromosome 4 open reading frame 27 | UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity) | 0.586 |
CALCOCO1 | ISOC1 | ENSP00000449960 | ENSP00000173527 | calcium binding and coiled-coil domain 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its inte [...] | isochorismatase domain containing 1 | 0.573 |
CAPNS1 | ISOC1 | ENSP00000246533 | ENSP00000173527 | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | isochorismatase domain containing 1 | 0.536 |
CAPNS1 | MYO1E | ENSP00000246533 | ENSP00000288235 | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | myosin IE; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by con [...] | 0.482 |
CAPNS1 | YWHAE | ENSP00000246533 | ENSP00000264335 | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.432 |
FAM110B | C4orf27 | ENSP00000355204 | ENSP00000406598 | family with sequence similarity 110, member B; May be involved in tumor progression | chromosome 4 open reading frame 27 | 0.583 |
FAM110B | ISOC1 | ENSP00000355204 | ENSP00000173527 | family with sequence similarity 110, member B; May be involved in tumor progression | isochorismatase domain containing 1 | 0.539 |
FAM110B | SPEF2 | ENSP00000355204 | ENSP00000348314 | family with sequence similarity 110, member B; May be involved in tumor progression | sperm flagellar 2; Required for correct axoneme development (By similarity) | 0.580 |
FAM110B | UFSP2 | ENSP00000355204 | ENSP00000264689 | family with sequence similarity 110, member B; May be involved in tumor progression | UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity) | 0.581 |
ISOC1 | C4orf27 | ENSP00000173527 | ENSP00000406598 | isochorismatase domain containing 1 | chromosome 4 open reading frame 27 | 0.559 |
ISOC1 | CALCOCO1 | ENSP00000173527 | ENSP00000449960 | isochorismatase domain containing 1 | calcium binding and coiled-coil domain 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its inte [...] | 0.573 |
ISOC1 | CAPNS1 | ENSP00000173527 | ENSP00000246533 | isochorismatase domain containing 1 | calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction | 0.536 |
ISOC1 | FAM110B | ENSP00000173527 | ENSP00000355204 | isochorismatase domain containing 1 | family with sequence similarity 110, member B; May be involved in tumor progression | 0.539 |
ISOC1 | MYO1E | ENSP00000173527 | ENSP00000288235 | isochorismatase domain containing 1 | myosin IE; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by con [...] | 0.538 |
ISOC1 | OLFML1 | ENSP00000173527 | ENSP00000332511 | isochorismatase domain containing 1 | olfactomedin-like 1 | 0.632 |
ISOC1 | RIOK2 | ENSP00000173527 | ENSP00000283109 | isochorismatase domain containing 1 | RIO kinase 2 (yeast) | 0.610 |
ISOC1 | SPEF2 | ENSP00000173527 | ENSP00000348314 | isochorismatase domain containing 1 | sperm flagellar 2; Required for correct axoneme development (By similarity) | 0.532 |