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STRINGSTRING
CALCOCO1 CALCOCO1 YWHAE YWHAE C4orf27 C4orf27 CAPNS1 CAPNS1 FAM110B FAM110B MYO1E MYO1E ISOC1 ISOC1 SPEF2 SPEF2 UFSP2 UFSP2 OLFML1 OLFML1 RIOK2 RIOK2
"ISOC1" - isochorismatase domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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[Homology]
Score
ISOC1isochorismatase domain containing 1 (298 aa)    
Predicted Functional Partners:
OLFML1
olfactomedin-like 1 (402 aa)
            score_image   0.632
RIOK2
RIO kinase 2 (yeast) (552 aa)
            score_image   0.610
CALCOCO1
calcium binding and coiled-coil domain 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its inte [...] (691 aa)
        score_image   score_image   0.573
C4orf27
chromosome 4 open reading frame 27 (346 aa)
            score_image   0.559
UFSP2
UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity) (469 aa)
            score_image   0.545
FAM110B
family with sequence similarity 110, member B; May be involved in tumor progression (370 aa)
            score_image   0.539
MYO1E
myosin IE; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by con [...] (1108 aa)
        score_image       0.538
CAPNS1
calpain, small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (268 aa)
        score_image   score_image   0.536
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (255 aa)
        score_image       0.534
SPEF2
sperm flagellar 2; Required for correct axoneme development (By similarity) (1822 aa)
            score_image   0.532
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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