node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARS | ASNS | ENSP00000261772 | ENSP00000175506 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | asparagine synthetase (glutamine-hydrolyzing) | 0.983 |
AARS | CAD | ENSP00000261772 | ENSP00000264705 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.732 |
AARS | EPRS | ENSP00000261772 | ENSP00000355890 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | glutamyl-prolyl-tRNA synthetase | 0.942 |
AARS | GARS | ENSP00000261772 | ENSP00000373918 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs | 0.998 |
AARS | IARS | ENSP00000261772 | ENSP00000364794 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | isoleucyl-tRNA synthetase | 0.995 |
AARS | UBC | ENSP00000261772 | ENSP00000344818 | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | ubiquitin C | 0.961 |
ASNS | AARS | ENSP00000175506 | ENSP00000261772 | asparagine synthetase (glutamine-hydrolyzing) | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) | 0.983 |
ASNS | ASS1 | ENSP00000175506 | ENSP00000253004 | asparagine synthetase (glutamine-hydrolyzing) | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.954 |
ASNS | ATF4 | ENSP00000175506 | ENSP00000336790 | asparagine synthetase (glutamine-hydrolyzing) | activating transcription factor 4 (tax-responsive enhancer element B67); Transcriptional activator. Binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert wit [...] | 0.992 |
ASNS | CAD | ENSP00000175506 | ENSP00000264705 | asparagine synthetase (glutamine-hydrolyzing) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.963 |
ASNS | EPRS | ENSP00000175506 | ENSP00000355890 | asparagine synthetase (glutamine-hydrolyzing) | glutamyl-prolyl-tRNA synthetase | 0.959 |
ASNS | GARS | ENSP00000175506 | ENSP00000373918 | asparagine synthetase (glutamine-hydrolyzing) | glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs | 0.989 |
ASNS | GOT1 | ENSP00000175506 | ENSP00000359539 | asparagine synthetase (glutamine-hydrolyzing) | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.939 |
ASNS | GOT2 | ENSP00000175506 | ENSP00000245206 | asparagine synthetase (glutamine-hydrolyzing) | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.938 |
ASNS | IARS | ENSP00000175506 | ENSP00000364794 | asparagine synthetase (glutamine-hydrolyzing) | isoleucyl-tRNA synthetase | 0.979 |
ASNS | UBC | ENSP00000175506 | ENSP00000344818 | asparagine synthetase (glutamine-hydrolyzing) | ubiquitin C | 0.947 |
ASS1 | ASNS | ENSP00000253004 | ENSP00000175506 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | asparagine synthetase (glutamine-hydrolyzing) | 0.954 |
ASS1 | CAD | ENSP00000253004 | ENSP00000264705 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.996 |
ASS1 | GOT1 | ENSP00000253004 | ENSP00000359539 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.910 |
ASS1 | GOT2 | ENSP00000253004 | ENSP00000245206 | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids | 0.911 |