CA12 protein (Homo sapiens) - STRING network view

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CA12

carbonic anhydrase XII; Reversible hydration of carbon dioxide (354 aa)

Predicted Functional Partners:

AKT1

0.817

HIF1AN

0.511

DNASE2B

0.461

DIRC2

0.440

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	CA12	ENSP00000270202	ENSP00000178638	v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...]	carbonic anhydrase XII; Reversible hydration of carbon dioxide	0.817
CA12	AKT1	ENSP00000178638	ENSP00000270202	carbonic anhydrase XII; Reversible hydration of carbon dioxide	v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...]	0.817
CA12	DIRC2	ENSP00000178638	ENSP00000261038	carbonic anhydrase XII; Reversible hydration of carbon dioxide	disrupted in renal carcinoma 2; Electrogenic metabolite transporter	0.440
CA12	DNASE2B	ENSP00000178638	ENSP00000359699	carbonic anhydrase XII; Reversible hydration of carbon dioxide	deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation	0.461
CA12	HIF1AN	ENSP00000178638	ENSP00000299163	carbonic anhydrase XII; Reversible hydration of carbon dioxide	hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...]	0.511
DIRC2	CA12	ENSP00000261038	ENSP00000178638	disrupted in renal carcinoma 2; Electrogenic metabolite transporter	carbonic anhydrase XII; Reversible hydration of carbon dioxide	0.440
DIRC2	HIF1AN	ENSP00000261038	ENSP00000299163	disrupted in renal carcinoma 2; Electrogenic metabolite transporter	hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...]	0.456
DNASE2B	CA12	ENSP00000359699	ENSP00000178638	deoxyribonuclease II beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation	carbonic anhydrase XII; Reversible hydration of carbon dioxide	0.461
HIF1AN	CA12	ENSP00000299163	ENSP00000178638	hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...]	carbonic anhydrase XII; Reversible hydration of carbon dioxide	0.511
HIF1AN	DIRC2	ENSP00000299163	ENSP00000261038	hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...]	disrupted in renal carcinoma 2; Electrogenic metabolite transporter	0.456

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