ARPP21 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ARPP21

cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity) (812 aa)

Predicted Functional Partners:

BDNF

0.834

CARM1

0.833

ARPP19

0.815

PPP1R1B

0.753

UQCRC2

0.724

ENSA

0.722

PLOD1

0.586

ANKRD2

0.555

C12orf39

0.507

BFSP2

0.504

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD2	ARPP19	ENSP00000306163	ENSP00000249822	ankyrin repeat domain 2 (stretch responsive muscle); May play an important role in skeletal muscle hypertrophy	cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression	0.707
ANKRD2	ARPP21	ENSP00000306163	ENSP00000187397	ankyrin repeat domain 2 (stretch responsive muscle); May play an important role in skeletal muscle hypertrophy	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	0.555
ARPP19	ANKRD2	ENSP00000249822	ENSP00000306163	cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression	ankyrin repeat domain 2 (stretch responsive muscle); May play an important role in skeletal muscle hypertrophy	0.707
ARPP19	ARPP21	ENSP00000249822	ENSP00000187397	cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	0.815
ARPP19	ENSA	ENSP00000249822	ENSP00000341743	cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression	endosulfine alpha	0.902
ARPP19	PPP1R1B	ENSP00000249822	ENSP00000254079	cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression	protein phosphatase 1, regulatory (inhibitor) subunit 1B; Inhibitor of protein-phosphatase 1	0.685
ARPP21	ANKRD2	ENSP00000187397	ENSP00000306163	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	ankyrin repeat domain 2 (stretch responsive muscle); May play an important role in skeletal muscle hypertrophy	0.555
ARPP21	ARPP19	ENSP00000187397	ENSP00000249822	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	cAMP-regulated phosphoprotein, 19kDa; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression	0.815
ARPP21	BDNF	ENSP00000187397	ENSP00000414303	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	brain-derived neurotrophic factor	0.834
ARPP21	BFSP2	ENSP00000187397	ENSP00000304987	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	beaded filament structural protein 2, phakinin; Involved in stabilization of lens fiber cell cytoskeleton (By similarity)	0.504
ARPP21	C12orf39	ENSP00000187397	ENSP00000256969	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	chromosome 12 open reading frame 39; Induces contraction of stomach muscle	0.507
ARPP21	CARM1	ENSP00000187397	ENSP00000325690	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	coactivator-associated arginine methyltransferase 1; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at ’Arg-17’ (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/ [...]	0.833
ARPP21	ENSA	ENSP00000187397	ENSP00000341743	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	endosulfine alpha	0.722
ARPP21	PLOD1	ENSP00000187397	ENSP00000196061	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links	0.586
ARPP21	PPP1R1B	ENSP00000187397	ENSP00000254079	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	protein phosphatase 1, regulatory (inhibitor) subunit 1B; Inhibitor of protein-phosphatase 1	0.753
ARPP21	UQCRC2	ENSP00000187397	ENSP00000268379	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	ubiquinol-cytochrome c reductase core protein II; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex	0.724
BDNF	ARPP21	ENSP00000414303	ENSP00000187397	brain-derived neurotrophic factor	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	0.834
BDNF	PPP1R1B	ENSP00000414303	ENSP00000254079	brain-derived neurotrophic factor	protein phosphatase 1, regulatory (inhibitor) subunit 1B; Inhibitor of protein-phosphatase 1	0.903
BFSP2	ARPP21	ENSP00000304987	ENSP00000187397	beaded filament structural protein 2, phakinin; Involved in stabilization of lens fiber cell cytoskeleton (By similarity)	cAMP-regulated phosphoprotein, 21kDa; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons (By similarity)	0.504
BFSP2	C12orf39	ENSP00000304987	ENSP00000256969	beaded filament structural protein 2, phakinin; Involved in stabilization of lens fiber cell cytoskeleton (By similarity)	chromosome 12 open reading frame 39; Induces contraction of stomach muscle	0.757

page 1 of 2

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About