TMEM38A protein (Homo sapiens) - STRING network view

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TMEM38A

transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity) (299 aa)

Predicted Functional Partners:

TMEM70

0.674

TMEM214

0.669

TMEM194A

0.668

RHBDD1

0.638

KLHL31

0.622

TMEM201

0.583

DHRS7

0.569

TMTC3

0.563

TMEM209

0.538

WFS1

0.526

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHRS7	TMEM209	ENSP00000216500	ENSP00000380747	dehydrogenase/reductase (SDR family) member 7	transmembrane protein 209	0.484
DHRS7	TMEM38A	ENSP00000216500	ENSP00000187762	dehydrogenase/reductase (SDR family) member 7	transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity)	0.569
DHRS7	TMEM70	ENSP00000216500	ENSP00000312599	dehydrogenase/reductase (SDR family) member 7	transmembrane protein 70; Involved in biogenesis of mitochondrial ATP synthase	0.443
KLHL31	RHBDD1	ENSP00000359942	ENSP00000344779	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	0.622
KLHL31	TMEM194A	ENSP00000359942	ENSP00000300128	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	transmembrane protein 194A	0.651
KLHL31	TMEM214	ENSP00000359942	ENSP00000238788	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	transmembrane protein 214	0.693
KLHL31	TMEM38A	ENSP00000359942	ENSP00000187762	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity)	0.622
KLHL31	TMEM70	ENSP00000359942	ENSP00000312599	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	transmembrane protein 70; Involved in biogenesis of mitochondrial ATP synthase	0.578
KLHL31	WFS1	ENSP00000359942	ENSP00000226760	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	Wolfram syndrome 1 (wolframin); Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store	0.436
RHBDD1	KLHL31	ENSP00000344779	ENSP00000359942	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	0.622
RHBDD1	TMEM194A	ENSP00000344779	ENSP00000300128	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	transmembrane protein 194A	0.498
RHBDD1	TMEM214	ENSP00000344779	ENSP00000238788	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	transmembrane protein 214	0.668
RHBDD1	TMEM38A	ENSP00000344779	ENSP00000187762	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity)	0.638
RHBDD1	WFS1	ENSP00000344779	ENSP00000226760	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	Wolfram syndrome 1 (wolframin); Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store	0.506
TMEM194A	KLHL31	ENSP00000300128	ENSP00000359942	transmembrane protein 194A	kelch-like 31 (Drosophila); Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE)	0.651
TMEM194A	RHBDD1	ENSP00000300128	ENSP00000344779	transmembrane protein 194A	rhomboid domain containing 1; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the trans [...]	0.498
TMEM194A	TMEM214	ENSP00000300128	ENSP00000238788	transmembrane protein 194A	transmembrane protein 214	0.528
TMEM194A	TMEM38A	ENSP00000300128	ENSP00000187762	transmembrane protein 194A	transmembrane protein 38A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity)	0.668
TMEM194A	TMEM70	ENSP00000300128	ENSP00000312599	transmembrane protein 194A	transmembrane protein 70; Involved in biogenesis of mitochondrial ATP synthase	0.636
TMEM194A	WFS1	ENSP00000300128	ENSP00000226760	transmembrane protein 194A	Wolfram syndrome 1 (wolframin); Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store	0.540

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