DMRT3 protein (Homo sapiens) - STRING network view

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Score

DMRT3

doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity) (472 aa)

Predicted Functional Partners:

RSPH1

0.861

TSGA10

0.842

TESK1

0.825

TSPY1

0.814

TSPY10

0.813

TSPYL1

0.758

TESK2

0.755

LIMK2

0.752

TSN

0.685

SPRY4

0.654

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMRT3	LIMK2	ENSP00000190165	ENSP00000339916	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	LIM domain kinase 2; Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro	0.752
DMRT3	RSPH1	ENSP00000190165	ENSP00000291536	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	radial spoke head 1 homolog (Chlamydomonas); May play an important role in male meiosis (By similarity)	0.861
DMRT3	SPRY4	ENSP00000190165	ENSP00000344967	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	sprouty homolog 4 (Drosophila); Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1	0.654
DMRT3	TESK1	ENSP00000190165	ENSP00000338127	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	testis-specific kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)	0.825
DMRT3	TESK2	ENSP00000190165	ENSP00000361158	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	testis-specific kinase 2; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at ’Ser-3’. May play an important role in spermatogenesis	0.755
DMRT3	TSGA10	ENSP00000190165	ENSP00000347161	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	testis specific, 10; May play a role in the sperm tail fibrous sheath, a major sperm tail structure (By similarity)	0.842
DMRT3	TSN	ENSP00000190165	ENSP00000374332	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots	0.685
DMRT3	TSPY1	ENSP00000190165	ENSP00000403304	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	testis specific protein, Y-linked 1; May be involved in sperm differentiation and proliferation	0.814
DMRT3	TSPY10	ENSP00000190165	ENSP00000406407	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	testis specific protein, Y-linked 10; Unknown. May be involved in sperm differentiation and proliferation (By similarity)	0.813
DMRT3	TSPYL1	ENSP00000190165	ENSP00000357597	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	TSPY-like 1	0.758
LIMK2	DMRT3	ENSP00000339916	ENSP00000190165	LIM domain kinase 2; Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.752
RSPH1	DMRT3	ENSP00000291536	ENSP00000190165	radial spoke head 1 homolog (Chlamydomonas); May play an important role in male meiosis (By similarity)	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.861
SPRY4	DMRT3	ENSP00000344967	ENSP00000190165	sprouty homolog 4 (Drosophila); Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.654
SPRY4	TESK1	ENSP00000344967	ENSP00000338127	sprouty homolog 4 (Drosophila); Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1	testis-specific kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)	0.938
TESK1	DMRT3	ENSP00000338127	ENSP00000190165	testis-specific kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.825
TESK1	SPRY4	ENSP00000338127	ENSP00000344967	testis-specific kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)	sprouty homolog 4 (Drosophila); Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1	0.938
TESK2	DMRT3	ENSP00000361158	ENSP00000190165	testis-specific kinase 2; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at ’Ser-3’. May play an important role in spermatogenesis	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.755
TSGA10	DMRT3	ENSP00000347161	ENSP00000190165	testis specific, 10; May play a role in the sperm tail fibrous sheath, a major sperm tail structure (By similarity)	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.842
TSN	DMRT3	ENSP00000374332	ENSP00000190165	translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.685
TSPY1	DMRT3	ENSP00000403304	ENSP00000190165	testis specific protein, Y-linked 1; May be involved in sperm differentiation and proliferation	doublesex and mab-3 related transcription factor 3; May regulate transcription during sexual development (By similarity)	0.814

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