| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ERLEC1 | KIAA0141 | ENSP00000185150 | ENSP00000194118 | endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.867 |
| ERLEC1 | OS9 | ENSP00000185150 | ENSP00000318165 | endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.709 |
| KIAA0141 | ERLEC1 | ENSP00000194118 | ENSP00000185150 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non-glycosylated proteins and glycoproteins | 0.867 |
| KIAA0141 | LIAS | ENSP00000194118 | ENSP00000261434 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | 0.700 |
| KIAA0141 | MAEA | ENSP00000194118 | ENSP00000302830 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.667 |
| KIAA0141 | MSRB1 | ENSP00000194118 | ENSP00000355084 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | methionine sulfoxide reductase B1 | 0.700 |
| KIAA0141 | OS9 | ENSP00000194118 | ENSP00000318165 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.852 |
| KIAA0141 | PARL | ENSP00000194118 | ENSP00000325421 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | 0.720 |
| KIAA0141 | PHB2 | ENSP00000194118 | ENSP00000441875 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.664 |
| KIAA0141 | PSMD9 | ENSP00000194118 | ENSP00000440485 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | proteasome (prosome, macropain) 26S subunit, non-ATPase, 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9-PSMC6-PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process | 0.669 |
| KIAA0141 | TOR1A | ENSP00000194118 | ENSP00000345719 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.748 |
| KIAA0141 | UBXN11 | ENSP00000194118 | ENSP00000363338 | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | UBX domain protein 11 | 0.703 |
| LIAS | KIAA0141 | ENSP00000261434 | ENSP00000194118 | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.700 |
| LIAS | MAEA | ENSP00000261434 | ENSP00000302830 | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.752 |
| LIAS | MSRB1 | ENSP00000261434 | ENSP00000355084 | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | methionine sulfoxide reductase B1 | 0.700 |
| LIAS | PARL | ENSP00000261434 | ENSP00000325421 | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | 0.828 |
| LIAS | PHB2 | ENSP00000261434 | ENSP00000441875 | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.743 |
| LIAS | UBXN11 | ENSP00000261434 | ENSP00000363338 | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | UBX domain protein 11 | 0.721 |
| MAEA | KIAA0141 | ENSP00000302830 | ENSP00000194118 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | KIAA0141; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation | 0.667 |
| MAEA | LIAS | ENSP00000302830 | ENSP00000261434 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) | 0.752 |
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