ADAM11 protein (Homo sapiens) - STRING network view

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ADAM11

ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (769 aa)

Predicted Functional Partners:

SPAG9

0.680

LGI4

0.611

RTN4R

0.605

LGI3

0.572

LGI1

0.527

FASTKD2

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM11	FASTKD2	ENSP00000200557	ENSP00000236980	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	FAST kinase domains 2	0.410
ADAM11	LGI1	ENSP00000200557	ENSP00000360472	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	leucine-rich, glioma inactivated 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival	0.527
ADAM11	LGI3	ENSP00000200557	ENSP00000302297	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	leucine-rich repeat LGI family, member 3; May participate in the regulation of neuronal exocytosis (By similarity)	0.572
ADAM11	LGI4	ENSP00000200557	ENSP00000312273	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	leucine-rich repeat LGI family, member 4	0.611
ADAM11	RTN4R	ENSP00000200557	ENSP00000043402	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	reticulon 4 receptor; Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity)	0.605
ADAM11	SPAG9	ENSP00000200557	ENSP00000262013	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	sperm associated antigen 9	0.680
FASTKD2	ADAM11	ENSP00000236980	ENSP00000200557	FAST kinase domains 2	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	0.410
FASTKD2	LGI1	ENSP00000236980	ENSP00000360472	FAST kinase domains 2	leucine-rich, glioma inactivated 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival	0.505
LGI1	ADAM11	ENSP00000360472	ENSP00000200557	leucine-rich, glioma inactivated 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	0.527
LGI1	FASTKD2	ENSP00000360472	ENSP00000236980	leucine-rich, glioma inactivated 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival	FAST kinase domains 2	0.505
LGI3	ADAM11	ENSP00000302297	ENSP00000200557	leucine-rich repeat LGI family, member 3; May participate in the regulation of neuronal exocytosis (By similarity)	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	0.572
LGI4	ADAM11	ENSP00000312273	ENSP00000200557	leucine-rich repeat LGI family, member 4	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	0.611
RTN4R	ADAM11	ENSP00000043402	ENSP00000200557	reticulon 4 receptor; Receptor for RTN4, OMG and MAG. Mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. Acts in conjunction with RTN4 and LIGO1 in regulating neuronal precursor cell motility during cortical development (By similarity)	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	0.605
SPAG9	ADAM11	ENSP00000262013	ENSP00000200557	sperm associated antigen 9	ADAM metallopeptidase domain 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein	0.680

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