| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKT2 | RALA | ENSP00000375892 | ENSP00000005257 | v-akt murine thymoma viral oncogene homolog 2; AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | 0.951 |
| AKT2 | RALGAPA2 | ENSP00000375892 | ENSP00000202677 | v-akt murine thymoma viral oncogene homolog 2; AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.901 |
| AKT2 | RALGAPB | ENSP00000375892 | ENSP00000262879 | v-akt murine thymoma viral oncogene homolog 2; AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.905 |
| EIF2A | ENSG00000212857 | ENSP00000417229 | ENSP00000375387 | eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins | Uncharacterized protein DKFZp434B061 | 0.568 |
| EIF2A | FREM3 | ENSP00000417229 | ENSP00000332886 | eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins | FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity) | 0.502 |
| EIF2A | RALGAPA2 | ENSP00000417229 | ENSP00000202677 | eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.456 |
| ENSG00000212857 | EIF2A | ENSP00000375387 | ENSP00000417229 | Uncharacterized protein DKFZp434B061 | eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins | 0.568 |
| ENSG00000212857 | FREM3 | ENSP00000375387 | ENSP00000332886 | Uncharacterized protein DKFZp434B061 | FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity) | 0.508 |
| ENSG00000212857 | RALGAPA2 | ENSP00000375387 | ENSP00000202677 | Uncharacterized protein DKFZp434B061 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.472 |
| FREM3 | EIF2A | ENSP00000332886 | ENSP00000417229 | FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity) | eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins | 0.502 |
| FREM3 | ENSG00000212857 | ENSP00000332886 | ENSP00000375387 | FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity) | Uncharacterized protein DKFZp434B061 | 0.508 |
| FREM3 | RALGAPA2 | ENSP00000332886 | ENSP00000202677 | FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity) | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.423 |
| PLEKHN1 | RALGAPA2 | ENSP00000368720 | ENSP00000202677 | pleckstrin homology domain containing, family N member 1 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.407 |
| RALA | AKT2 | ENSP00000005257 | ENSP00000375892 | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | v-akt murine thymoma viral oncogene homolog 2; AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.951 |
| RALA | RALGAPA2 | ENSP00000005257 | ENSP00000202677 | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.915 |
| RALA | RALGAPB | ENSP00000005257 | ENSP00000262879 | v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.923 |
| RALGAPA2 | AKT2 | ENSP00000202677 | ENSP00000375892 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | v-akt murine thymoma viral oncogene homolog 2; AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 0.901 |
| RALGAPA2 | EIF2A | ENSP00000202677 | ENSP00000417229 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | eukaryotic translation initiation factor 2A, 65kDa; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF- 2 complex, it binds methionyl-tRNAi to 40 S subunits in a codon- dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40 S subunits in a GTP-dependent manner. May act by impiging the expression of specific proteins | 0.456 |
| RALGAPA2 | ENSG00000212857 | ENSP00000202677 | ENSP00000375387 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | Uncharacterized protein DKFZp434B061 | 0.472 |
| RALGAPA2 | FREM3 | ENSP00000202677 | ENSP00000332886 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | FRAS1 related extracellular matrix 3; Extracellular matrix protein which may play a role in cell adhesion (By similarity) | 0.423 |
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