| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALDH16A1 | SPG21 | ENSP00000293350 | ENSP00000204566 | aldehyde dehydrogenase 16 family, member A1 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.757 |
| ALDH16A1 | UBC | ENSP00000293350 | ENSP00000344818 | aldehyde dehydrogenase 16 family, member A1 | ubiquitin C | 0.916 |
| CD4 | SPG21 | ENSP00000011653 | ENSP00000204566 | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.924 |
| CTPS2 | SPG21 | ENSP00000352222 | ENSP00000204566 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.727 |
| CTPS2 | UBC | ENSP00000352222 | ENSP00000344818 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | ubiquitin C | 0.697 |
| MAGI2 | MAST1 | ENSP00000346151 | ENSP00000251472 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | microtubule associated serine/threonine kinase 1; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity) | 0.748 |
| MAGI2 | MAST2 | ENSP00000346151 | ENSP00000354671 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | microtubule associated serine/threonine kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity) | 0.748 |
| MAGI2 | SPG21 | ENSP00000346151 | ENSP00000204566 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.730 |
| MAGI3 | MAST3 | ENSP00000304604 | ENSP00000262811 | membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] | microtubule associated serine/threonine kinase 3 | 0.750 |
| MAGI3 | SPG21 | ENSP00000304604 | ENSP00000204566 | membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.743 |
| MAGI3 | UBC | ENSP00000304604 | ENSP00000344818 | membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] | ubiquitin C | 0.483 |
| MAST1 | MAGI2 | ENSP00000251472 | ENSP00000346151 | microtubule associated serine/threonine kinase 1; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity) | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.748 |
| MAST1 | SPG21 | ENSP00000251472 | ENSP00000204566 | microtubule associated serine/threonine kinase 1; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity) | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.743 |
| MAST2 | MAGI2 | ENSP00000354671 | ENSP00000346151 | microtubule associated serine/threonine kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity) | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.748 |
| MAST2 | SPG21 | ENSP00000354671 | ENSP00000204566 | microtubule associated serine/threonine kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity) | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.743 |
| MAST3 | MAGI3 | ENSP00000262811 | ENSP00000304604 | microtubule associated serine/threonine kinase 3 | membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] | 0.750 |
| MAST3 | SPG21 | ENSP00000262811 | ENSP00000204566 | microtubule associated serine/threonine kinase 3 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | 0.743 |
| SPG21 | ALDH16A1 | ENSP00000204566 | ENSP00000293350 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | aldehyde dehydrogenase 16 family, member A1 | 0.757 |
| SPG21 | CD4 | ENSP00000204566 | ENSP00000011653 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | CD4 molecule; Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts | 0.924 |
| SPG21 | CTPS2 | ENSP00000204566 | ENSP00000352222 | spastic paraplegia 21 (autosomal recessive, Mast syndrome); May play a role as a negative regulatory factor in CD4- dependent T-cell activation | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides | 0.727 |
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