node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP1 | BMP2 | ENSP00000305714 | ENSP00000368104 | bone morphogenetic protein 1 | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.879 |
BMP1 | BMP4 | ENSP00000305714 | ENSP00000245451 | bone morphogenetic protein 1 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.880 |
BMP1 | BMP5 | ENSP00000305714 | ENSP00000359866 | bone morphogenetic protein 1 | bone morphogenetic protein 5; Induces cartilage and bone formation | 0.635 |
BMP1 | BMP6 | ENSP00000305714 | ENSP00000283147 | bone morphogenetic protein 1 | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.575 |
BMP1 | BMP7 | ENSP00000305714 | ENSP00000379204 | bone morphogenetic protein 1 | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.635 |
BMP1 | BMPR1A | ENSP00000305714 | ENSP00000224764 | bone morphogenetic protein 1 | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | 0.400 |
BMP1 | CHRD | ENSP00000305714 | ENSP00000204604 | bone morphogenetic protein 1 | chordin | 0.996 |
BMP1 | TLL1 | ENSP00000305714 | ENSP00000061240 | bone morphogenetic protein 1 | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.901 |
BMP1 | TWSG1 | ENSP00000305714 | ENSP00000262120 | bone morphogenetic protein 1 | twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) | 0.802 |
BMP2 | BMP1 | ENSP00000368104 | ENSP00000305714 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 1 | 0.879 |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | BMP5 | ENSP00000368104 | ENSP00000359866 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 5; Induces cartilage and bone formation | 0.969 |
BMP2 | BMP6 | ENSP00000368104 | ENSP00000283147 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.709 |
BMP2 | BMP7 | ENSP00000368104 | ENSP00000379204 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis | 0.968 |
BMP2 | BMPR1A | ENSP00000368104 | ENSP00000224764 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type IA; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | 0.999 |
BMP2 | BMPR1B | ENSP00000368104 | ENSP00000264568 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein receptor, type IB; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5 | 0.999 |
BMP2 | CHRD | ENSP00000368104 | ENSP00000204604 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin | 0.999 |
BMP2 | TLL1 | ENSP00000368104 | ENSP00000061240 | bone morphogenetic protein 2; Induces cartilage and bone formation | tolloid-like 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis | 0.790 |
BMP2 | TWSG1 | ENSP00000368104 | ENSP00000262120 | bone morphogenetic protein 2; Induces cartilage and bone formation | twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) | 0.854 |
BMP4 | BMP1 | ENSP00000245451 | ENSP00000305714 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 1 | 0.880 |