NAT14 protein (Homo sapiens) - STRING network view

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NAT14

N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (206 aa)

Predicted Functional Partners:

CENPE

0.483

KIF23

0.459

KIF11

0.452

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CENPE	KIF11	ENSP00000265148	ENSP00000260731	centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]	kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays	0.786
CENPE	KIF23	ENSP00000265148	ENSP00000260363	centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]	kinesin family member 23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro	0.481
CENPE	NAT14	ENSP00000265148	ENSP00000205194	centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]	N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro	0.483
KIF11	CENPE	ENSP00000260731	ENSP00000265148	kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays	centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]	0.786
KIF11	KIF23	ENSP00000260731	ENSP00000260363	kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays	kinesin family member 23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro	0.884
KIF11	NAT14	ENSP00000260731	ENSP00000205194	kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays	N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro	0.452
KIF23	CENPE	ENSP00000260363	ENSP00000265148	kinesin family member 23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro	centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]	0.481
KIF23	KIF11	ENSP00000260363	ENSP00000260731	kinesin family member 23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro	kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays	0.884
KIF23	NAT14	ENSP00000260363	ENSP00000205194	kinesin family member 23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro	N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro	0.459
NAT14	CENPE	ENSP00000205194	ENSP00000265148	N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro	centromere protein E, 312kDa; Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynami [...]	0.483
NAT14	KIF11	ENSP00000205194	ENSP00000260731	N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro	kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays	0.452
NAT14	KIF23	ENSP00000205194	ENSP00000260363	N-acetyltransferase 14 (GCN5-related, putative); Probable acetyltransferase that binds the 5’-GGACTACAG- 3’ sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro	kinesin family member 23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro	0.459

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