| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTR5 | TMEM101 | ENSP00000243903 | ENSP00000206380 | ARP5 actin-related protein 5 homolog (yeast); Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair | transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.453 |
| C6orf70 | COG7 | ENSP00000355735 | ENSP00000305442 | chromosome 6 open reading frame 70 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | 0.485 |
| C6orf70 | FHAD1 | ENSP00000355735 | ENSP00000365167 | chromosome 6 open reading frame 70 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.497 |
| C6orf70 | HEATR7A | ENSP00000355735 | ENSP00000321737 | chromosome 6 open reading frame 70 | HEAT repeat containing 7A | 0.507 |
| C6orf70 | TMEM101 | ENSP00000355735 | ENSP00000206380 | chromosome 6 open reading frame 70 | transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.485 |
| CC2D1A | COG7 | ENSP00000313601 | ENSP00000305442 | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | 0.535 |
| CC2D1A | FHAD1 | ENSP00000313601 | ENSP00000365167 | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.584 |
| CC2D1A | HEATR7A | ENSP00000313601 | ENSP00000321737 | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | HEAT repeat containing 7A | 0.410 |
| CC2D1A | PGAM5 | ENSP00000313601 | ENSP00000438465 | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | 0.428 |
| CC2D1A | TMEM101 | ENSP00000313601 | ENSP00000206380 | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.521 |
| COG7 | C6orf70 | ENSP00000305442 | ENSP00000355735 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | chromosome 6 open reading frame 70 | 0.485 |
| COG7 | CC2D1A | ENSP00000305442 | ENSP00000313601 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | 0.535 |
| COG7 | FHAD1 | ENSP00000305442 | ENSP00000365167 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.638 |
| COG7 | HEATR7A | ENSP00000305442 | ENSP00000321737 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | HEAT repeat containing 7A | 0.434 |
| COG7 | PGAM5 | ENSP00000305442 | ENSP00000438465 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | phosphoglycerate mutase family member 5; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore | 0.483 |
| COG7 | TMEM101 | ENSP00000305442 | ENSP00000206380 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.578 |
| FBXO25 | TMEM101 | ENSP00000276326 | ENSP00000206380 | F-box protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity) | transmembrane protein 101; May activate NF-kappa-B signaling pathways | 0.577 |
| FHAD1 | C6orf70 | ENSP00000365167 | ENSP00000355735 | forkhead-associated (FHA) phosphopeptide binding domain 1 | chromosome 6 open reading frame 70 | 0.497 |
| FHAD1 | CC2D1A | ENSP00000365167 | ENSP00000313601 | forkhead-associated (FHA) phosphopeptide binding domain 1 | coiled-coil and C2 domain containing 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasm [...] | 0.584 |
| FHAD1 | COG7 | ENSP00000365167 | ENSP00000305442 | forkhead-associated (FHA) phosphopeptide binding domain 1 | component of oligomeric golgi complex 7; Required for normal Golgi function (By similarity) | 0.638 |
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