node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADH1A | ALDH1A1 | ENSP00000209668 | ENSP00000297785 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | 0.974 |
ADH1A | ALDH1A2 | ENSP00000209668 | ENSP00000249750 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) | 0.939 |
ADH1A | ALDH1A3 | ENSP00000209668 | ENSP00000332256 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | 0.957 |
ADH1A | ALDH1B1 | ENSP00000209668 | ENSP00000366927 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | 0.971 |
ADH1A | ALDH3A1 | ENSP00000209668 | ENSP00000225740 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.957 |
ADH1A | ALDH3A2 | ENSP00000209668 | ENSP00000345774 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.963 |
ADH1A | ALDH3B2 | ENSP00000209668 | ENSP00000255084 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 3 family, member B2 | 0.964 |
ADH1A | AOX1 | ENSP00000209668 | ENSP00000363832 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde oxidase 1 | 0.950 |
ADH1A | CYP26A1 | ENSP00000209668 | ENSP00000224356 | alcohol dehydrogenase 1A (class I), alpha polypeptide | cytochrome P450, family 26, subfamily A, polypeptide 1; Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA | 0.944 |
ADH1A | GSTP1 | ENSP00000209668 | ENSP00000381607 | alcohol dehydrogenase 1A (class I), alpha polypeptide | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.938 |
ALDH1A1 | ADH1A | ENSP00000297785 | ENSP00000209668 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.974 |
ALDH1A1 | CYP26A1 | ENSP00000297785 | ENSP00000224356 | aldehyde dehydrogenase 1 family, member A1; Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity) | cytochrome P450, family 26, subfamily A, polypeptide 1; Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA | 0.963 |
ALDH1A2 | ADH1A | ENSP00000249750 | ENSP00000209668 | aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.939 |
ALDH1A2 | CYP26A1 | ENSP00000249750 | ENSP00000224356 | aldehyde dehydrogenase 1 family, member A2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity) | cytochrome P450, family 26, subfamily A, polypeptide 1; Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA | 0.982 |
ALDH1A3 | ADH1A | ENSP00000332256 | ENSP00000209668 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.957 |
ALDH1A3 | CYP26A1 | ENSP00000332256 | ENSP00000224356 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | cytochrome P450, family 26, subfamily A, polypeptide 1; Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18- hydroxylation. Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA and 18-OH-RA | 0.693 |
ALDH1A3 | GSTP1 | ENSP00000332256 | ENSP00000381607 | aldehyde dehydrogenase 1 family, member A3; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity) | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.916 |
ALDH1B1 | ADH1A | ENSP00000366927 | ENSP00000209668 | aldehyde dehydrogenase 1 family, member B1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.971 |
ALDH3A1 | ADH1A | ENSP00000225740 | ENSP00000209668 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.957 |
ALDH3A1 | GSTP1 | ENSP00000225740 | ENSP00000381607 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.928 |