TECR protein (Homo sapiens) - STRING network view

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TECR

trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids (308 aa)

Predicted Functional Partners:

UBC

0.988

PTPLB

0.988

ELOVL1

0.932

ACOT7

0.900

ACOT4

0.900

ACOT1

0.900

ACOT2

0.900

ERMAP

0.889

PECR

0.846

ELOVL7

0.837

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOT1	ACOT7	ENSP00000311224	ENSP00000367086	acyl-CoA thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)	acyl-CoA thioesterase 7	0.567
ACOT1	TECR	ENSP00000311224	ENSP00000215567	acyl-CoA thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.900
ACOT1	UBC	ENSP00000311224	ENSP00000344818	acyl-CoA thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)	ubiquitin C	0.645
ACOT2	TECR	ENSP00000238651	ENSP00000215567	acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.900
ACOT2	UBC	ENSP00000238651	ENSP00000344818	acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs	ubiquitin C	0.809
ACOT4	TECR	ENSP00000323071	ENSP00000215567	acyl-CoA thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.900
ACOT7	ACOT1	ENSP00000367086	ENSP00000311224	acyl-CoA thioesterase 7	acyl-CoA thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)	0.567
ACOT7	TECR	ENSP00000367086	ENSP00000215567	acyl-CoA thioesterase 7	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.900
ACOT7	UBC	ENSP00000367086	ENSP00000344818	acyl-CoA thioesterase 7	ubiquitin C	0.922
ELOVL1	TECR	ENSP00000361536	ENSP00000215567	ELOVL fatty acid elongase 1; Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22-0 acyl-CoA. Important for saturated C24-0 and monounsaturated C24-1 sphingolipid synthesis	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.932
ELOVL1	UBC	ENSP00000361536	ENSP00000344818	ELOVL fatty acid elongase 1; Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22-0 acyl-CoA. Important for saturated C24-0 and monounsaturated C24-1 sphingolipid synthesis	ubiquitin C	0.836
ELOVL7	TECR	ENSP00000402634	ENSP00000215567	ELOVL fatty acid elongase 7; Condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18-3(n-3) acyl-CoAs and C18-3(n-6)-CoAs. Also active toward C20-4-, C18-0-, C18-1-, C18-2- and C16-0-CoAs, and weakly toward C20-0-CoA. Little or no activity toward C22-0-, C24-0-, or C26-0-CoAs	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.837
ERMAP	TECR	ENSP00000361592	ENSP00000215567	erythroblast membrane-associated protein (Scianna blood group)	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.889
PECR	TECR	ENSP00000265322	ENSP00000215567	peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.846
PTPLB	TECR	ENSP00000373153	ENSP00000215567	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	0.988
PTPLB	UBC	ENSP00000373153	ENSP00000344818	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis	ubiquitin C	0.620
TECR	ACOT1	ENSP00000215567	ENSP00000311224	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	acyl-CoA thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity)	0.900
TECR	ACOT2	ENSP00000215567	ENSP00000238651	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	acyl-CoA thioesterase 2; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs	0.900
TECR	ACOT4	ENSP00000215567	ENSP00000323071	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	acyl-CoA thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (By similarity). Succinyl-CoA thioesterase that also hydrolyzes long chain saturated and unsaturated monocarboxylic acyl-CoAs	0.900
TECR	ACOT7	ENSP00000215567	ENSP00000367086	trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids	acyl-CoA thioesterase 7	0.900

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