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FKBP8 FKBP8 KLHL6 KLHL6 PAPOLG PAPOLG UBC UBC ZBTB1 ZBTB1 ZBTB48 ZBTB48 ZBTB5 ZBTB5 LZTR1 LZTR1 FAM57A FAM57A TBX1 TBX1 ZBTB34 ZBTB34
"LZTR1" - leucine-zipper-like transcription regulator 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
LZTR1leucine-zipper-like transcription regulator 1; Probable transcriptional regulator that may play a crucial role in embryogenesis (840 aa)    
Predicted Functional Partners:
TBX1
T-box 1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity) (495 aa)
            score_image   0.743
ZBTB48
zinc finger and BTB domain containing 48; Binds to and regulates the J and/or S elements in MHC II promoter (688 aa)
            score_image   0.660
UBC
ubiquitin C (685 aa)
        score_image       0.620
KLHL6
kelch-like 6 (Drosophila); Involved in B-lymphocyte antigen receptor signaling and germinal center formation (By similarity) (621 aa)
            score_image   0.528
ZBTB5
zinc finger and BTB domain containing 5; May be involved in transcriptional regulation (677 aa)
            score_image   0.522
ZBTB34
zinc finger and BTB domain containing 34; May be a transcriptional repressor (500 aa)
            score_image   0.486
FAM57A
family with sequence similarity 57, member A (257 aa)
            score_image   0.485
ZBTB1
zinc finger and BTB domain containing 1; May be involved in transcriptional regulation (713 aa)
        score_image   score_image score_image 0.463
PAPOLG
poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3’-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA (736 aa)
        score_image   score_image   0.427
FKBP8
FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (413 aa)
            score_image   0.421
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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