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DCT DCT POTEF POTEF TSPO TSPO ACTB ACTB UNG UNG GAPDH GAPDH HPRT1 HPRT1 DDT DDT UBC UBC DSTYK DSTYK IL6 IL6
"DDT" - D-dopachrome tautomerase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DDTD-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) (118 aa)    
Predicted Functional Partners:
IL6
interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] (212 aa)
            score_image   0.863
DCT
dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels (552 aa)
            score_image   0.757
GAPDH
glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] (335 aa)
      score_image     score_image   0.749
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.659
TSPO
translocator protein (18kDa); Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity) (169 aa)
            score_image   0.584
DSTYK
dual serine/threonine and tyrosine protein kinase (929 aa)
        score_image       0.540
HPRT1
hypoxanthine phosphoribosyltransferase 1; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (218 aa)
      score_image     score_image   0.485
UNG
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) (313 aa)
            score_image   0.472
POTEF
POTE ankyrin domain family, member F (1075 aa)
            score_image   0.470
ACTB
actin, beta (375 aa)
            score_image   0.468
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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