node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTB | DDT | ENSP00000349960 | ENSP00000215773 | actin, beta | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | 0.468 |
ACTB | GAPDH | ENSP00000349960 | ENSP00000229239 | actin, beta | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.956 |
ACTB | HPRT1 | ENSP00000349960 | ENSP00000298556 | actin, beta | hypoxanthine phosphoribosyltransferase 1; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway | 0.794 |
ACTB | TSPO | ENSP00000349960 | ENSP00000328973 | actin, beta | translocator protein (18kDa); Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity) | 0.587 |
ACTB | UBC | ENSP00000349960 | ENSP00000344818 | actin, beta | ubiquitin C | 0.999 |
DCT | DDT | ENSP00000392762 | ENSP00000215773 | dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | 0.757 |
DCT | GAPDH | ENSP00000392762 | ENSP00000229239 | dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.662 |
DCT | HPRT1 | ENSP00000392762 | ENSP00000298556 | dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels | hypoxanthine phosphoribosyltransferase 1; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway | 0.405 |
DCT | TSPO | ENSP00000392762 | ENSP00000328973 | dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels | translocator protein (18kDa); Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity) | 0.581 |
DCT | UNG | ENSP00000392762 | ENSP00000242576 | dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) | 0.405 |
DDT | ACTB | ENSP00000215773 | ENSP00000349960 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | actin, beta | 0.468 |
DDT | DCT | ENSP00000215773 | ENSP00000392762 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | dopachrome tautomerase; Involved in regulating eumelanin and phaeomelanin levels | 0.757 |
DDT | DSTYK | ENSP00000215773 | ENSP00000356130 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | dual serine/threonine and tyrosine protein kinase | 0.540 |
DDT | GAPDH | ENSP00000215773 | ENSP00000229239 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.749 |
DDT | HPRT1 | ENSP00000215773 | ENSP00000298556 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | hypoxanthine phosphoribosyltransferase 1; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway | 0.485 |
DDT | IL6 | ENSP00000215773 | ENSP00000258743 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.863 |
DDT | POTEF | ENSP00000215773 | ENSP00000350052 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | POTE ankyrin domain family, member F | 0.470 |
DDT | TSPO | ENSP00000215773 | ENSP00000328973 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | translocator protein (18kDa); Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity) | 0.584 |
DDT | UBC | ENSP00000215773 | ENSP00000344818 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | ubiquitin C | 0.659 |
DDT | UNG | ENSP00000215773 | ENSP00000242576 | D-dopachrome tautomerase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) | 0.472 |