MORC2 protein (Homo sapiens) - STRING network view

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MORC2

MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression (970 aa)

Predicted Functional Partners:

CA9

0.811

UBC

0.795

HDAC4

0.599

TMEM175

0.583

CCDC157

0.578

VEZT

0.554

SUMO2

0.520

WDR75

0.501

SUN1

0.493

GAS2L3

0.488

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CA9	MORC2	ENSP00000367608	ENSP00000215862	carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	0.811
CCDC157	MORC2	ENSP00000343087	ENSP00000215862	coiled-coil domain containing 157	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	0.578
GAS2L3	MORC2	ENSP00000266754	ENSP00000215862	growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	0.488
GAS2L3	WDR75	ENSP00000266754	ENSP00000314193	growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network	WD repeat domain 75	0.633
HDAC4	MORC2	ENSP00000264606	ENSP00000215862	histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	0.599
HDAC4	SUMO2	ENSP00000264606	ENSP00000405965	histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	0.950
HDAC4	UBC	ENSP00000264606	ENSP00000344818	histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D	ubiquitin C	0.603
MORC2	CA9	ENSP00000215862	ENSP00000367608	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	carbonic anhydrase IX; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia	0.811
MORC2	CCDC157	ENSP00000215862	ENSP00000343087	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	coiled-coil domain containing 157	0.578
MORC2	GAS2L3	ENSP00000215862	ENSP00000266754	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	growth arrest-specific 2 like 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network	0.488
MORC2	HDAC4	ENSP00000215862	ENSP00000264606	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D	0.599
MORC2	SUMO2	ENSP00000215862	ENSP00000405965	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	0.520
MORC2	SUN1	ENSP00000215862	ENSP00000384015	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	Sad1 and UNC84 domain containing 1	0.493
MORC2	TMEM175	ENSP00000215862	ENSP00000264771	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	transmembrane protein 175	0.583
MORC2	UBC	ENSP00000215862	ENSP00000344818	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	ubiquitin C	0.795
MORC2	VEZT	ENSP00000215862	ENSP00000410083	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	vezatin, adherens junctions transmembrane protein; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site	0.554
MORC2	WDR75	ENSP00000215862	ENSP00000314193	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	WD repeat domain 75	0.501
SUMO2	HDAC4	ENSP00000405965	ENSP00000264606	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D	0.950
SUMO2	MORC2	ENSP00000405965	ENSP00000215862	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	MORC family CW-type zinc finger 2; May act as a transcriptional repressor. Down-regulates CA9 expression	0.520
SUMO2	UBC	ENSP00000405965	ENSP00000344818	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...]	ubiquitin C	0.999

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