LGALS2 protein (Homo sapiens) - STRING network view

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LGALS2

lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known (132 aa)

Predicted Functional Partners:

BRAP

0.832

LGALS9

0.668

PLA2G12B

0.589

LTA

0.585

TUBA4A

0.582

EGFR

0.574

TNFSF15

0.573

TUBA1B

0.573

TUBA1A

0.573

ABHD2

0.566

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD2	LGALS2	ENSP00000268129	ENSP00000215886	abhydrolase domain containing 2; May play a role in smooth muscle cells migration (By similarity)	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	0.566
BRAP	LGALS2	ENSP00000403524	ENSP00000215886	BRCA1 associated protein; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	0.832
EGFR	LGALS2	ENSP00000275493	ENSP00000215886	epidermal growth factor receptor	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	0.574
EGFR	TUBA1A	ENSP00000275493	ENSP00000301071	epidermal growth factor receptor	tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.827
EGFR	TUBA4A	ENSP00000275493	ENSP00000248437	epidermal growth factor receptor	tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.683
LGALS2	ABHD2	ENSP00000215886	ENSP00000268129	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	abhydrolase domain containing 2; May play a role in smooth muscle cells migration (By similarity)	0.566
LGALS2	BRAP	ENSP00000215886	ENSP00000403524	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	BRCA1 associated protein; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport	0.832
LGALS2	EGFR	ENSP00000215886	ENSP00000275493	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	epidermal growth factor receptor	0.574
LGALS2	LGALS9	ENSP00000215886	ENSP00000378856	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	lectin, galactoside-binding, soluble, 9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant	0.668
LGALS2	LTA	ENSP00000215886	ENSP00000403495	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo	0.585
LGALS2	PLA2G12B	ENSP00000215886	ENSP00000362123	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity	0.589
LGALS2	TNFSF15	ENSP00000215886	ENSP00000363157	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	tumor necrosis factor (ligand) superfamily, member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis	0.573
LGALS2	TUBA1A	ENSP00000215886	ENSP00000301071	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.573
LGALS2	TUBA1B	ENSP00000215886	ENSP00000336799	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	tubulin, alpha 1b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.573
LGALS2	TUBA4A	ENSP00000215886	ENSP00000248437	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	tubulin, alpha 4a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.582
LGALS9	LGALS2	ENSP00000378856	ENSP00000215886	lectin, galactoside-binding, soluble, 9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	0.668
LTA	LGALS2	ENSP00000403495	ENSP00000215886	lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	0.585
LTA	TUBA1A	ENSP00000403495	ENSP00000301071	lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo	tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.573
LTA	TUBA1B	ENSP00000403495	ENSP00000336799	lymphotoxin alpha (TNF superfamily, member 1); Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo	tubulin, alpha 1b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)	0.573
PLA2G12B	LGALS2	ENSP00000362123	ENSP00000215886	phospholipase A2, group XIIB; Not known; does not seem to have catalytic activity	lectin, galactoside-binding, soluble, 2; This protein binds beta-galactoside. Its physiological function is not yet known	0.589

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