| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FDX1 | FDX1L | ENSP00000260270 | ENSP00000377311 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | 0.660 |
| FDX1 | FXN | ENSP00000260270 | ENSP00000366482 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.762 |
| FDX1 | HSCB | ENSP00000260270 | ENSP00000216027 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria | 0.957 |
| FDX1 | HSPA4 | ENSP00000260270 | ENSP00000302961 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | heat shock 70kDa protein 4 | 0.618 |
| FDX1 | HSPA9 | ENSP00000260270 | ENSP00000297185 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | heat shock 70kDa protein 9 (mortalin) | 0.656 |
| FDX1 | ISCA1 | ENSP00000260270 | ENSP00000365159 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly | 0.826 |
| FDX1 | ISCA2 | ENSP00000260270 | ENSP00000452007 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | iron-sulfur cluster assembly 2 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity) | 0.817 |
| FDX1 | ISCU | ENSP00000260270 | ENSP00000310623 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron | 0.958 |
| FDX1 | NFS1 | ENSP00000260270 | ENSP00000363205 | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | NFS1 nitrogen fixation 1 homolog (S. cerevisiae); Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor | 0.931 |
| FDX1L | FDX1 | ENSP00000377311 | ENSP00000260270 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 0.660 |
| FDX1L | FXN | ENSP00000377311 | ENSP00000366482 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.604 |
| FDX1L | HSCB | ENSP00000377311 | ENSP00000216027 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | HscB iron-sulfur cluster co-chaperone homolog (E. coli); Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria | 0.848 |
| FDX1L | HSPA4 | ENSP00000377311 | ENSP00000302961 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | heat shock 70kDa protein 4 | 0.535 |
| FDX1L | HSPA9 | ENSP00000377311 | ENSP00000297185 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | heat shock 70kDa protein 9 (mortalin) | 0.607 |
| FDX1L | ISCA1 | ENSP00000377311 | ENSP00000365159 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | iron-sulfur cluster assembly 1 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly | 0.796 |
| FDX1L | ISCA2 | ENSP00000377311 | ENSP00000452007 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | iron-sulfur cluster assembly 2 homolog (S. cerevisiae); Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity) | 0.763 |
| FDX1L | ISCU | ENSP00000377311 | ENSP00000310623 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | iron-sulfur cluster scaffold homolog (E. coli); Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron | 0.898 |
| FDX1L | NFS1 | ENSP00000377311 | ENSP00000363205 | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | NFS1 nitrogen fixation 1 homolog (S. cerevisiae); Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor | 0.903 |
| FXN | FDX1 | ENSP00000366482 | ENSP00000260270 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | ferredoxin 1; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage | 0.762 |
| FXN | FDX1L | ENSP00000366482 | ENSP00000377311 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | ferredoxin 1-like; Essential for heme A and Fe/S protein biosynthesis | 0.604 |
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