Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RTDR1 | rhabdoid tumor deletion region gene 1 (348 aa) | ||||||||||||
Predicted Functional Partners:
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 | RAB36 | RAB36, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (333 aa) |
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0.890 | ||||||||||
 | RAB13 | RAB13, member RAS oncogene family; Could participate in polarized transport, in the assembly and/or the activity of tight junctions (203 aa) |
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0.871 | ||||||||||
 | ZDHHC20 | zinc finger, DHHC-type containing 20 (354 aa) |
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0.820 | |||||||||
 | ZDHHC15 | zinc finger, DHHC-type containing 15; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) (337 aa) |
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0.820 | |||||||||
 | ZDHHC2 | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) (367 aa) |
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0.820 | |||||||||
 | RAB23 | RAB23, member RAS oncogene family; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates [...] (237 aa) |
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0.760 | ||||||||||
 | TMCO7 | transmembrane and coiled-coil domains 7 (1094 aa) |
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0.716 | ||||||||||
 | HEATR4 | HEAT repeat containing 4 (1026 aa) |
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0.716 | ||||||||||
 | YKT6 | YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (198 aa) |
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0.715 | |||||||||
 | VTI1B | vesicle transport through interaction with t-SNAREs homolog 1B (yeast); V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence (232 aa) |
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0.647 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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