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STRINGSTRING
BAX BAX ALG12 ALG12 UBC UBC RTCA RTCA C22orf28 C22orf28 FAM98A FAM98A C14orf166 C14orf166 DDX1 DDX1 FAM98B FAM98B ZBTB8OS ZBTB8OS C2orf49 C2orf49
"C22orf28" - chromosome 22 open reading frame 28 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
C22orf28chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (505 aa)    
Predicted Functional Partners:
FAM98B
family with sequence similarity 98, member B (433 aa)
        score_image score_image score_image   0.999
C2orf49
chromosome 2 open reading frame 49 (232 aa)
        score_image score_image score_image   0.999
C14orf166
chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication (244 aa)
        score_image score_image score_image   0.999
DDX1
DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] (740 aa)
      score_image score_image score_image score_image   0.997
UBC
ubiquitin C (685 aa)
        score_image       0.981
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand (179 aa)
score_image   score_image   score_image   score_image   0.886
RTCA
RNA 3’-terminal phosphate cyclase; Catalyzes the conversion of 3’-phosphate to a 2’,3’- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps- (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3’P to produce RNA- N3’PP5’A; (C) and attack of the adjacent 2’-hydroxyl on the 3’- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (379 aa)
score_image   score_image score_image     score_image   0.839
ALG12
asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae); Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP- Man(7)GlcNAc(2)) required for protein glycosylation (488 aa)
      score_image     score_image   0.666
FAM98A
family with sequence similarity 98, member A (518 aa)
            score_image   0.651
BAX
BCL2-associated X protein (218 aa)
            score_image   0.613
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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