splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes: protein of unknown 3D structure
large nodes: some 3D structure is known or predicted
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C22orf31
chromosome 22 open reading frame 31 (290 aa)
Predicted Functional Partners:
ZFAND3
zinc finger, AN1-type domain 3 (227 aa)
0.469
CD1A
CD1a molecule; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells (327 aa)
0.414
TCEAL4
transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation (215 aa)
0.410
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606 Other names: H. sapiens, Homo, Homo sapiens, human, man
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1
node2
node1 accession
node2 accession
node1 annotation
node2 annotation
score
C22orf31
CD1A
ENSP00000216071
ENSP00000289429
chromosome 22 open reading frame 31
CD1a molecule; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells
0.414
C22orf31
TCEAL4
ENSP00000216071
ENSP00000415564
chromosome 22 open reading frame 31
transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation
0.410
C22orf31
ZFAND3
ENSP00000216071
ENSP00000287218
chromosome 22 open reading frame 31
zinc finger, AN1-type domain 3
0.469
CD1A
C22orf31
ENSP00000289429
ENSP00000216071
CD1a molecule; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells
chromosome 22 open reading frame 31
0.414
TCEAL4
C22orf31
ENSP00000415564
ENSP00000216071
transcription elongation factor A (SII)-like 4; May be involved in transcriptional regulation
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
Neighborhood
Groups of genes that are frequently observed in each other's genomic neighborhood.
Databases
Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
Fusion
Genes that are sometimes fused into single open reading frames.
Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
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Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: