Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | NIPSNAP1 | nipsnap homolog 1 (C. elegans) (284 aa) | ||||||||||||
Predicted Functional Partners:
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 | TRPV6 | transient receptor potential cation channel, subfamily V, member 6; Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin- dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. H [...] (725 aa) |
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0.972 | ||||||||||
 | GBAS | glioblastoma amplified sequence (286 aa) |
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0.939 | ||||||||
 | TRPV5 | transient receptor potential cation channel, subfamily V, member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity) (729 aa) |
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0.751 | ||||||||||
 | THOC5 | THO complex 5; Component the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5’ end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi’s sarcoma-associa [...] (683 aa) |
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0.746 | ||||||||||
 | UBC | ubiquitin C (685 aa) |
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0.721 | ||||||||||
 | CHCHD1 | coiled-coil-helix-coiled-coil-helix domain containing 1 (118 aa) |
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0.529 | ||||||||||
 | METTL17 | methyltransferase like 17; May be a component of the mitochondrial small ribosomal subunit (By similarity) (478 aa) |
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0.495 | ||||||||||
 | SEC14L1 | SEC14-like 1 (S. cerevisiae) (719 aa) |
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0.489 | ||||||||||
 | SEC14L5 | SEC14-like 5 (S. cerevisiae) (696 aa) |
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0.489 | ||||||||||
 | MORC1 | MORC family CW-type zinc finger 1; Required for spermatogenesis (By similarity) (984 aa) |
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0.461 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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