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STRINGSTRING
GALC GALC ARSH ARSH ARSA ARSA ARSI ARSI ARSK ARSK ARSD ARSD SUMF2 SUMF2 STS STS ARSJ ARSJ SUMF1 SUMF1 ARSB ARSB
"ARSA" - arylsulfatase A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARSAarylsulfatase A; Hydrolyzes cerebroside sulfate (509 aa)    
Predicted Functional Partners:
SUMF1
sulfatase modifying factor 1 (374 aa)
score_image   score_image     score_image score_image   0.985
SUMF2
sulfatase modifying factor 2 (358 aa)
score_image   score_image     score_image score_image   0.960
GALC
galactosylceramidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon (685 aa)
          score_image score_image   0.959
ARSB
arylsulfatase B (533 aa)
    score_image     score_image score_image score_image 0.936
ARSK
arylsulfatase family, member K (536 aa)
    score_image     score_image score_image score_image 0.930
ARSJ
arylsulfatase family, member J (599 aa)
    score_image     score_image score_image score_image 0.928
ARSI
arylsulfatase family, member I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts (569 aa)
    score_image     score_image score_image score_image 0.928
STS
steroid sulfatase (microsomal), isozyme S; Conversion of sulfated steroid precursors to estrogens during pregnancy (583 aa)
    score_image     score_image score_image score_image 0.925
ARSH
arylsulfatase family, member H (562 aa)
    score_image     score_image score_image score_image 0.924
ARSD
arylsulfatase D (593 aa)
  score_image score_image     score_image score_image score_image 0.923
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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