node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF17 | CD248 | ENSP00000263674 | ENSP00000308117 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | CD248 molecule, endosialin; May play a role in tumor angiogenesis | 0.814 |
ARHGEF17 | GPR124 | ENSP00000263674 | ENSP00000406367 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) | 0.814 |
ARHGEF17 | IPO5 | ENSP00000263674 | ENSP00000261574 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.408 |
ARHGEF17 | OXA1L | ENSP00000263674 | ENSP00000285848 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | 0.457 |
ARHGEF17 | PLXDC1 | ENSP00000263674 | ENSP00000323927 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | plexin domain containing 1; Plays a critical role in endothelial cell capillary morphogenesis (By similarity) | 0.847 |
ARHGEF17 | RASD2 | ENSP00000263674 | ENSP00000216127 | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination | 0.757 |
CD248 | ARHGEF17 | ENSP00000308117 | ENSP00000263674 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | 0.814 |
CD248 | GPR124 | ENSP00000308117 | ENSP00000406367 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) | 0.813 |
CD248 | IPO5 | ENSP00000308117 | ENSP00000261574 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.816 |
CD248 | OXA1L | ENSP00000308117 | ENSP00000285848 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | oxidase (cytochrome c) assembly 1-like; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria | 0.878 |
CD248 | PLXDC1 | ENSP00000308117 | ENSP00000323927 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | plexin domain containing 1; Plays a critical role in endothelial cell capillary morphogenesis (By similarity) | 0.906 |
CD248 | RASD2 | ENSP00000308117 | ENSP00000216127 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination | 0.943 |
CD248 | SERPINB5 | ENSP00000308117 | ENSP00000372221 | CD248 molecule, endosialin; May play a role in tumor angiogenesis | serpin peptidase inhibitor, clade B (ovalbumin), member 5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity | 0.815 |
GNB1 | RASD2 | ENSP00000367869 | ENSP00000216127 | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination | 0.720 |
GPR124 | ARHGEF17 | ENSP00000406367 | ENSP00000263674 | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | 0.814 |
GPR124 | CD248 | ENSP00000406367 | ENSP00000308117 | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) | CD248 molecule, endosialin; May play a role in tumor angiogenesis | 0.813 |
GPR124 | PLXDC1 | ENSP00000406367 | ENSP00000323927 | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) | plexin domain containing 1; Plays a critical role in endothelial cell capillary morphogenesis (By similarity) | 0.878 |
GPR124 | RASD2 | ENSP00000406367 | ENSP00000216127 | G protein-coupled receptor 124; Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity) | RASD family, member 2; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination | 0.856 |
IPO5 | ARHGEF17 | ENSP00000261574 | ENSP00000263674 | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | Rho guanine nucleotide exchange factor (GEF) 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases | 0.408 |
IPO5 | CD248 | ENSP00000261574 | ENSP00000308117 | importin 5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | CD248 molecule, endosialin; May play a role in tumor angiogenesis | 0.816 |