| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TRIP6 | TTLL12 | ENSP00000200457 | ENSP00000216129 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | tubulin tyrosine ligase-like family, member 12 | 0.910 |
| TRIP6 | UBC | ENSP00000200457 | ENSP00000344818 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | ubiquitin C | 0.483 |
| TRIP6 | UBE2C | ENSP00000200457 | ENSP00000348838 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | ubiquitin-conjugating enzyme E2C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating ’Lys-11’-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit | 0.907 |
| TRIP6 | UFM1 | ENSP00000200457 | ENSP00000239878 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1 | 0.893 |
| TRIP6 | UNK | ENSP00000200457 | ENSP00000293218 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | unkempt homolog (Drosophila) | 0.818 |
| TTLL12 | TRIP6 | ENSP00000216129 | ENSP00000200457 | tubulin tyrosine ligase-like family, member 12 | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | 0.910 |
| TTLL12 | UBC | ENSP00000216129 | ENSP00000344818 | tubulin tyrosine ligase-like family, member 12 | ubiquitin C | 0.945 |
| TTLL12 | UBE2C | ENSP00000216129 | ENSP00000348838 | tubulin tyrosine ligase-like family, member 12 | ubiquitin-conjugating enzyme E2C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating ’Lys-11’-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit | 0.914 |
| TTLL12 | UBE2D1 | ENSP00000216129 | ENSP00000363019 | tubulin tyrosine ligase-like family, member 12 | ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...] | 0.905 |
| TTLL12 | UBE2V2 | ENSP00000216129 | ENSP00000428209 | tubulin tyrosine ligase-like family, member 12 | ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through ’Lys-63’. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage | 0.913 |
| TTLL12 | UBXN7 | ENSP00000216129 | ENSP00000296328 | tubulin tyrosine ligase-like family, member 12 | UBX domain protein 7 | 0.913 |
| TTLL12 | UFM1 | ENSP00000216129 | ENSP00000239878 | tubulin tyrosine ligase-like family, member 12 | ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1 | 0.905 |
| TTLL12 | UNK | ENSP00000216129 | ENSP00000293218 | tubulin tyrosine ligase-like family, member 12 | unkempt homolog (Drosophila) | 0.905 |
| TTLL12 | USP34 | ENSP00000216129 | ENSP00000381577 | tubulin tyrosine ligase-like family, member 12 | ubiquitin specific peptidase 34 | 0.916 |
| TTLL12 | ZRANB2 | ENSP00000216129 | ENSP00000359958 | tubulin tyrosine ligase-like family, member 12 | zinc finger, RAN-binding domain containing 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5’- splice site selection | 0.924 |
| UBC | TRIP6 | ENSP00000344818 | ENSP00000200457 | ubiquitin C | thyroid hormone receptor interactor 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor | 0.483 |
| UBC | TTLL12 | ENSP00000344818 | ENSP00000216129 | ubiquitin C | tubulin tyrosine ligase-like family, member 12 | 0.945 |
| UBC | UBE2C | ENSP00000344818 | ENSP00000348838 | ubiquitin C | ubiquitin-conjugating enzyme E2C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’- and ’Lys-48’-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating ’Lys-11’-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit | 0.999 |
| UBC | UBE2D1 | ENSP00000344818 | ENSP00000363019 | ubiquitin C | ubiquitin-conjugating enzyme E2D 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyu [...] | 0.999 |
| UBC | UBE2V2 | ENSP00000344818 | ENSP00000428209 | ubiquitin C | ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through ’Lys-63’. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage | 0.999 |
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