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PPAT PPAT PAICS PAICS GMPS GMPS GART GART ADSS ADSS PFAS PFAS APRT APRT ATIC ATIC ADSL ADSL ADSSL1 ADSSL1 ADK ADK
"ADSL" - adenylosuccinate lyase in Homo sapiens
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Predicted Interactions
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ADSLadenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis- converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate (484 aa)    
Predicted Functional Partners:
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (432 aa)
score_image     score_image score_image score_image score_image   0.998
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa)
score_image     score_image   score_image score_image   0.996
ADSS
adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) (456 aa)
score_image   score_image score_image   score_image score_image   0.996
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (1010 aa)
score_image     score_image     score_image   0.992
ADSSL1
adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) (500 aa)
score_image   score_image score_image   score_image score_image   0.989
PFAS
phosphoribosylformylglycinamidine synthase (1338 aa)
score_image     score_image     score_image   0.978
APRT
adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (180 aa)
      score_image score_image score_image score_image   0.975
GMPS
guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division (693 aa)
score_image     score_image     score_image   0.965
ADK
adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides (362 aa)
      score_image score_image score_image score_image   0.965
PPAT
phosphoribosyl pyrophosphate amidotransferase (517 aa)
score_image     score_image score_image   score_image   0.964
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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