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IDH2 IDH2 IDH3A IDH3A IDH3B IDH3B IDH3G IDH3G FXN FXN ACO2 ACO2 ACLY ACLY CS CS IDH1 IDH1 ACAT1 ACAT1 ACAA2 ACAA2
"ACO2" - aconitase 2, mitochondrial in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
ACO2aconitase 2, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity) (780 aa)    
Predicted Functional Partners:
CS
citrate synthase (466 aa)
score_image     score_image score_image score_image score_image   0.997
IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha (366 aa)
score_image     score_image   score_image score_image   0.994
IDH3B
isocitrate dehydrogenase 3 (NAD+) beta (385 aa)
score_image     score_image   score_image score_image   0.993
IDH2
isocitrate dehydrogenase 2 (NADP+), mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (452 aa)
score_image     score_image score_image score_image score_image   0.991
IDH1
isocitrate dehydrogenase 1 (NADP+), soluble (414 aa)
score_image     score_image score_image score_image score_image   0.989
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
score_image     score_image score_image   score_image   0.963
ACAA2
acetyl-CoA acyltransferase 2; Abolishes BNIP3-mediated apoptosis and mitochondrial damage (397 aa)
      score_image score_image   score_image   0.945
ACAT1
acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
        score_image   score_image   0.943
FXN
frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] (210 aa)
        score_image   score_image   0.927
IDH3G
isocitrate dehydrogenase 3 (NAD+) gamma (393 aa)
score_image     score_image     score_image   0.926
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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