Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SOS2 | son of sevenless homolog 2 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP (By similarity) (1332 aa) | ||||||||||||
Predicted Functional Partners:
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 | GRB2 | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (217 aa) |
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0.999 | ||||||||
 | EGFR | epidermal growth factor receptor (1210 aa) |
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0.996 | ||||||||
 | HRAS | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa) |
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0.981 | ||||||||
 | GRAP2 | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc (330 aa) |
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0.973 | |||||||||
 | GRAP | GRB2-related adaptor protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway (217 aa) |
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0.971 | |||||||||
 | VAV2 | vav 2 guanine nucleotide exchange factor (878 aa) |
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0.962 | |||||||||
 | NCK2 | NCK adaptor protein 2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling (380 aa) |
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0.961 | ||||||||
 | RRAS | related RAS viral (r-ras) oncogene homolog; Regulates the organization of the actin cytoskeleton (218 aa) |
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0.959 | ||||||||
 | SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 (584 aa) |
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0.957 | |||||||||
 | GRAPL | GRB2-related adaptor protein-like (118 aa) |
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0.942 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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