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STRINGSTRING
AMY2A AMY2A AMY2B AMY2B AGL AGL AMY1A AMY1A PGM1 PGM1 GBE1 GBE1 PYGL PYGL GYS2 GYS2 UBC UBC GYS1 GYS1 UGP2 UGP2
"PYGL" - phosphorylase, glycogen, liver in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PYGLphosphorylase, glycogen, liver; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) (847 aa)    
Predicted Functional Partners:
GBE1
glucan (1,4-alpha-), branching enzyme 1; Required for sufficient glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule and, consequently, in reducing the osmotic pressure within cells (702 aa)
score_image     score_image   score_image score_image   0.998
AGL
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase (1532 aa)
score_image     score_image   score_image score_image   0.998
GYS2
glycogen synthase 2 (liver); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan (703 aa)
score_image     score_image   score_image score_image   0.996
GYS1
glycogen synthase 1 (muscle); Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan (737 aa)
score_image     score_image   score_image score_image   0.993
PGM1
phosphoglucomutase 1 (580 aa)
score_image     score_image   score_image score_image   0.990
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.983
UGP2
UDP-glucose pyrophosphorylase 2; Plays a central role as a glucosyl donor in cellular metabolic pathways (508 aa)
      score_image   score_image score_image   0.965
AMY1A
amylase, alpha 1A (salivary) (511 aa)
score_image     score_image score_image score_image score_image   0.954
AMY2A
amylase, alpha 2A (pancreatic) (511 aa)
score_image     score_image score_image score_image score_image   0.953
AMY2B
amylase, alpha 2B (pancreatic) (511 aa)
score_image     score_image score_image score_image score_image   0.953
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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