SLC10A1 protein (Homo sapiens) - STRING network view

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SLC10A1

solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium (349 aa)

Predicted Functional Partners:

ABCC3

0.975

FABP6

0.968

ALB

0.939

ABCB11

0.917

SLCO1A2

0.915

SLCO1B1

0.904

ENSG00000257046

0.897

SLCO1B3

0.897

SLCO1C1

0.877

IL6

0.854

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB11	ALB	ENSP00000263817	ENSP00000295897	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	albumin	0.412
ABCB11	ENSG00000257046	ENSP00000263817	ENSP00000441269	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	0.782
ABCB11	FABP6	ENSP00000263817	ENSP00000377549	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis	0.757
ABCB11	IL6	ENSP00000263817	ENSP00000258743	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...]	0.855
ABCB11	SLC10A1	ENSP00000263817	ENSP00000216540	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium	0.917
ABCB11	SLCO1A2	ENSP00000263817	ENSP00000305974	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.813
ABCB11	SLCO1B1	ENSP00000263817	ENSP00000256958	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver	0.851
ABCB11	SLCO1B3	ENSP00000263817	ENSP00000261196	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver	0.782
ABCB11	SLCO1C1	ENSP00000263817	ENSP00000370964	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity)	0.722
ABCC3	ALB	ENSP00000285238	ENSP00000295897	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	albumin	0.925
ABCC3	ENSG00000257046	ENSP00000285238	ENSP00000441269	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein	0.757
ABCC3	FABP6	ENSP00000285238	ENSP00000377549	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis	0.933
ABCC3	SLC10A1	ENSP00000285238	ENSP00000216540	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium	0.975
ABCC3	SLCO1A2	ENSP00000285238	ENSP00000305974	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin	0.973
ABCC3	SLCO1B1	ENSP00000285238	ENSP00000256958	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver	0.977
ABCC3	SLCO1B3	ENSP00000285238	ENSP00000261196	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver	0.974
ABCC3	SLCO1C1	ENSP00000285238	ENSP00000370964	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity)	0.615
ALB	ABCB11	ENSP00000295897	ENSP00000263817	albumin	ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes	0.412
ALB	ABCC3	ENSP00000295897	ENSP00000285238	albumin	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	0.925
ALB	FABP6	ENSP00000295897	ENSP00000377549	albumin	fatty acid binding protein 6, ileal; Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis	0.928

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