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NPLOC4 NPLOC4 VAT1 VAT1 RTN4 RTN4 ZFYVE21 ZFYVE21 VTN VTN PTK2 PTK2 COL1A1 COL1A1 TYMS TYMS FN1 FN1 ITGB1 ITGB1 TLN1 TLN1
"ZFYVE21" - zinc finger, FYVE domain containing 21 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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textmining
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protein homology
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ZFYVE21zinc finger, FYVE domain containing 21; Plays a role in cell adhesion, and thereby in cell motility, regulating microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassemblya, as well as integrin beta-1/ITGB1 cell surface expression (252 aa)    
Predicted Functional Partners:
PTK2
PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] (1065 aa)
             score_image   0.893
VAT1
vesicle amine transport protein 1 homolog (T. californica); Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (393 aa)
         score_image       0.644
TYMS
thymidylate synthetase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway (313 aa)
         score_image       0.644
TLN1
talin 1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) (2541 aa)
             score_image   0.610
VTN
vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (478 aa)
             score_image   0.606
RTN4
reticulon 4 (1192 aa)
         score_image       0.549
NPLOC4
nuclear protein localization 4 homolog (S. cerevisiae); The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity) (608 aa)
             score_image   0.496
FN1
fibronectin 1 (2477 aa)
             score_image   0.483
COL1A1
collagen, type I, alpha 1 (1464 aa)
             score_image   0.440
ITGB1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) (798 aa)
             score_image   0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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