| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGT | BDKRB1 | ENSP00000355627 | ENSP00000216629 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | 0.980 |
| AGT | BDKRB2 | ENSP00000355627 | ENSP00000307713 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.984 |
| AGT | CHRM1 | ENSP00000355627 | ENSP00000306490 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | cholinergic receptor, muscarinic 1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover | 0.900 |
| AGT | GNAQ | ENSP00000355627 | ENSP00000286548 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.925 |
| AGT | KNG1 | ENSP00000355627 | ENSP00000265023 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.989 |
| AGT | LPAR3 | ENSP00000355627 | ENSP00000359643 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins | 0.900 |
| AGT | NPY | ENSP00000355627 | ENSP00000242152 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.942 |
| AGT | OXTR | ENSP00000355627 | ENSP00000324270 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system | 0.908 |
| AGT | PLCB1 | ENSP00000355627 | ENSP00000338185 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | phospholipase C, beta 1 (phosphoinositide-specific) | 0.902 |
| AGT | PTGER3 | ENSP00000355627 | ENSP00000349003 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.927 |
| BDKRB1 | AGT | ENSP00000216629 | ENSP00000355627 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.980 |
| BDKRB1 | BDKRB2 | ENSP00000216629 | ENSP00000307713 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.911 |
| BDKRB1 | CHRM1 | ENSP00000216629 | ENSP00000306490 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | cholinergic receptor, muscarinic 1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover | 0.913 |
| BDKRB1 | GNAQ | ENSP00000216629 | ENSP00000286548 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity) | 0.966 |
| BDKRB1 | KNG1 | ENSP00000216629 | ENSP00000265023 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.983 |
| BDKRB1 | LPAR3 | ENSP00000216629 | ENSP00000359643 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins | 0.949 |
| BDKRB1 | NPY | ENSP00000216629 | ENSP00000242152 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.919 |
| BDKRB1 | OXTR | ENSP00000216629 | ENSP00000324270 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system | 0.920 |
| BDKRB1 | PLCB1 | ENSP00000216629 | ENSP00000338185 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | phospholipase C, beta 1 (phosphoinositide-specific) | 0.915 |
| BDKRB1 | PTGER3 | ENSP00000216629 | ENSP00000349003 | bradykinin receptor B1; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.916 |
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