node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNB1 | CCNB2 | ENSP00000256442 | ENSP00000288207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB1 | CDK1 | ENSP00000256442 | ENSP00000378699 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
CCNB1 | CDK2 | ENSP00000256442 | ENSP00000266970 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNB1 | CREBBP | ENSP00000256442 | ENSP00000262367 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | 0.540 |
CCNB1 | E2F4 | ENSP00000256442 | ENSP00000368686 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | E2F transcription factor 4, p107/p130-binding; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1 | 0.944 |
CCNB1 | LIN37 | ENSP00000256442 | ENSP00000301159 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | lin-37 homolog (C. elegans) | 0.904 |
CCNB1 | LIN54 | ENSP00000256442 | ENSP00000341947 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | lin-54 homolog (C. elegans); Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner | 0.924 |
CCNB1 | LIN9 | ENSP00000256442 | ENSP00000329102 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | lin-9 homolog (C. elegans); Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition | 0.919 |
CCNB1 | MYBL2 | ENSP00000256442 | ENSP00000217026 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | v-myb myeloblastosis viral oncogene homolog (avian)-like 2; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene | 0.992 |
CCNB1 | RBL1 | ENSP00000256442 | ENSP00000362768 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.745 |
CCNB2 | CCNB1 | ENSP00000288207 | ENSP00000256442 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB2 | CDK1 | ENSP00000288207 | ENSP00000378699 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
CCNB2 | CDK2 | ENSP00000288207 | ENSP00000266970 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNB2 | E2F4 | ENSP00000288207 | ENSP00000368686 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | E2F transcription factor 4, p107/p130-binding; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1 | 0.685 |
CCNB2 | LIN37 | ENSP00000288207 | ENSP00000301159 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | lin-37 homolog (C. elegans) | 0.904 |
CCNB2 | LIN54 | ENSP00000288207 | ENSP00000341947 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | lin-54 homolog (C. elegans); Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner | 0.921 |
CCNB2 | LIN9 | ENSP00000288207 | ENSP00000329102 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | lin-9 homolog (C. elegans); Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition | 0.913 |
CCNB2 | MYBL2 | ENSP00000288207 | ENSP00000217026 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | v-myb myeloblastosis viral oncogene homolog (avian)-like 2; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene | 0.991 |
CCNB2 | RBL1 | ENSP00000288207 | ENSP00000362768 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.614 |
CDK1 | CCNB1 | ENSP00000378699 | ENSP00000256442 | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.999 |