node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB11 | SLC10A1 | ENSP00000263817 | ENSP00000216540 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.917 |
ABCB11 | SLC22A7 | ENSP00000263817 | ENSP00000361666 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.609 |
ABCB11 | SLC22A8 | ENSP00000263817 | ENSP00000337335 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.543 |
ABCB11 | SLC22A9 | ENSP00000263817 | ENSP00000279178 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 22 (organic anion transporter), member 9 | 0.404 |
ABCB11 | SLCO4A1 | ENSP00000263817 | ENSP00000217159 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.706 |
ABCB11 | UBC | ENSP00000263817 | ENSP00000344818 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | ubiquitin C | 0.606 |
HPN | SLCO4A1 | ENSP00000262626 | ENSP00000217159 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.800 |
SLC10A1 | ABCB11 | ENSP00000216540 | ENSP00000263817 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.917 |
SLC10A1 | SLC22A6 | ENSP00000216540 | ENSP00000367102 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | solute carrier family 22 (organic anion transporter), member 6 | 0.431 |
SLC10A1 | SLC22A7 | ENSP00000216540 | ENSP00000361666 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.611 |
SLC10A1 | SLC22A8 | ENSP00000216540 | ENSP00000337335 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.571 |
SLC10A1 | SLCO4A1 | ENSP00000216540 | ENSP00000217159 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.837 |
SLC22A11 | SLCO4A1 | ENSP00000301891 | ENSP00000217159 | solute carrier family 22 (organic anion/urate transporter), member 11; Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.625 |
SLC22A6 | SLC10A1 | ENSP00000367102 | ENSP00000216540 | solute carrier family 22 (organic anion transporter), member 6 | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.431 |
SLC22A6 | SLCO4A1 | ENSP00000367102 | ENSP00000217159 | solute carrier family 22 (organic anion transporter), member 6 | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.634 |
SLC22A7 | ABCB11 | ENSP00000361666 | ENSP00000263817 | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.609 |
SLC22A7 | SLC10A1 | ENSP00000361666 | ENSP00000216540 | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.611 |
SLC22A7 | SLC29A2 | ENSP00000361666 | ENSP00000350024 | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | solute carrier family 29 (nucleoside transporters), member 2; Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine | 0.413 |
SLC22A7 | SLCO4A1 | ENSP00000361666 | ENSP00000217159 | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.584 |
SLC22A8 | ABCB11 | ENSP00000337335 | ENSP00000263817 | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.543 |