| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FLRT1 | FLRT2 | ENSP00000246841 | ENSP00000332879 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling | 0.603 |
| FLRT1 | MACROD2 | ENSP00000246841 | ENSP00000217246 | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | 0.584 |
| FLRT2 | FLRT1 | ENSP00000332879 | ENSP00000246841 | fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | 0.603 |
| FLRT2 | MACROD2 | ENSP00000332879 | ENSP00000217246 | fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | 0.582 |
| FLRT3 | MACROD2 | ENSP00000339912 | ENSP00000217246 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | 0.888 |
| FLRT3 | MLL2 | ENSP00000339912 | ENSP00000301067 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | myeloid/lymphoid or mixed-lineage leukemia 2; Histone methyltransferase. Methylates ’Lys-4’ of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription | 0.692 |
| FLRT3 | TGFBR1 | ENSP00000339912 | ENSP00000364133 | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | transforming growth factor, beta receptor 1; Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppres [...] | 0.406 |
| H2AFY2 | MACROD2 | ENSP00000362352 | ENSP00000217246 | H2A histone family, member Y2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome [...] | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | 0.526 |
| H2AFY2 | OSTM1 | ENSP00000362352 | ENSP00000193322 | H2A histone family, member Y2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome [...] | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.487 |
| H2AFY2 | UBC | ENSP00000362352 | ENSP00000344818 | H2A histone family, member Y2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome [...] | ubiquitin C | 0.831 |
| MACROD2 | FLRT1 | ENSP00000217246 | ENSP00000246841 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | fibronectin leucine rich transmembrane protein 1; May have a function in cell adhesion and/or receptor signaling | 0.584 |
| MACROD2 | FLRT2 | ENSP00000217246 | ENSP00000332879 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | fibronectin leucine rich transmembrane protein 2; May have a function in cell adhesion and/or receptor signaling | 0.582 |
| MACROD2 | FLRT3 | ENSP00000217246 | ENSP00000339912 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | fibronectin leucine rich transmembrane protein 3; May have a function in cell adhesion and/or receptor signaling | 0.888 |
| MACROD2 | H2AFY2 | ENSP00000217246 | ENSP00000362352 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | H2A histone family, member Y2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome [...] | 0.526 |
| MACROD2 | MLL2 | ENSP00000217246 | ENSP00000301067 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | myeloid/lymphoid or mixed-lineage leukemia 2; Histone methyltransferase. Methylates ’Lys-4’ of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription | 0.748 |
| MACROD2 | OARD1 | ENSP00000217246 | ENSP00000416829 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | O-acyl-ADP-ribose deacylase 1; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O- acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP- ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively | 0.549 |
| MACROD2 | OSTM1 | ENSP00000217246 | ENSP00000193322 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | osteopetrosis associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function (By similarity) | 0.487 |
| MACROD2 | PTCHD1 | ENSP00000217246 | ENSP00000368666 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | patched domain containing 1 | 0.409 |
| MACROD2 | TGFBR1 | ENSP00000217246 | ENSP00000364133 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | transforming growth factor, beta receptor 1; Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppres [...] | 0.483 |
| MACROD2 | UBC | ENSP00000217246 | ENSP00000344818 | MACRO domain containing 2; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins | ubiquitin C | 0.565 |
Share
