Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SPINT3 | serine peptidase inhibitor, Kunitz type, 3 (89 aa) | ||||||||||||
Predicted Functional Partners:
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 | WFDC9 | WAP four-disulfide core domain 9 (89 aa) |
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0.592 | ||||||||||
 | DEFB126 | defensin, beta 126; Has antibacterial activity (Potential) (111 aa) |
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0.589 | ||||||||||
 | TAF10 | TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (218 aa) |
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0.573 | ||||||||||
 | EDDM3A | epididymal protein 3A; Possible function in sperm maturation (147 aa) |
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0.497 | ||||||||||
 | EDDM3B | epididymal protein 3B; Possible function in sperm maturation (147 aa) |
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0.497 | ||||||||||
 | SPINK9 | serine peptidase inhibitor, Kazal type 9; Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5 (86 aa) |
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0.495 | ||||||||||
 | DEFB-30 | beta-defensin 130-like precursor ; Has antibacterial activity (Potential) (79 aa) |
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0.493 | ||||||||||
 | DEFB130 | defensin, beta 130; Has antibacterial activity (Potential) (79 aa) |
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0.493 | ||||||||||
 | DEFB135 | defensin, beta 135; Has antibacterial activity (Potential) (77 aa) |
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0.485 | ||||||||||
 | DEFB128 | defensin, beta 128; Has antibacterial activity (Potential) (93 aa) |
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0.483 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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