FAM83D protein (Homo sapiens) - STRING network view

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Score

FAM83D

family with sequence similarity 83, member D (615 aa)

Predicted Functional Partners:

UBC

0.854

CSNK1A1

0.738

PPP1R16B

0.660

CSNK1E

0.632

SLC32A1

0.594

KIF4A

0.552

PPP1R16A

0.456

KIF22

0.429

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSNK1A1	CSNK1E	ENSP00000421689	ENSP00000352929	casein kinase 1, alpha 1	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	0.598
CSNK1A1	FAM83D	ENSP00000421689	ENSP00000217429	casein kinase 1, alpha 1	family with sequence similarity 83, member D	0.738
CSNK1A1	UBC	ENSP00000421689	ENSP00000344818	casein kinase 1, alpha 1	ubiquitin C	0.948
CSNK1E	CSNK1A1	ENSP00000352929	ENSP00000421689	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	casein kinase 1, alpha 1	0.598
CSNK1E	FAM83D	ENSP00000352929	ENSP00000217429	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	family with sequence similarity 83, member D	0.632
CSNK1E	UBC	ENSP00000352929	ENSP00000344818	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	ubiquitin C	0.810
FAM83D	CSNK1A1	ENSP00000217429	ENSP00000421689	family with sequence similarity 83, member D	casein kinase 1, alpha 1	0.738
FAM83D	CSNK1E	ENSP00000217429	ENSP00000352929	family with sequence similarity 83, member D	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	0.632
FAM83D	KIF22	ENSP00000217429	ENSP00000160827	family with sequence similarity 83, member D	kinesin family member 22; Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA	0.429
FAM83D	KIF4A	ENSP00000217429	ENSP00000363524	family with sequence similarity 83, member D	kinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization	0.552
FAM83D	PPP1R16A	ENSP00000217429	ENSP00000292539	family with sequence similarity 83, member D	protein phosphatase 1, regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates (By similarity)	0.456
FAM83D	PPP1R16B	ENSP00000217429	ENSP00000299824	family with sequence similarity 83, member D	protein phosphatase 1, regulatory subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells	0.660
FAM83D	SLC32A1	ENSP00000217429	ENSP00000217420	family with sequence similarity 83, member D	solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles	0.594
FAM83D	UBC	ENSP00000217429	ENSP00000344818	family with sequence similarity 83, member D	ubiquitin C	0.854
KIF22	FAM83D	ENSP00000160827	ENSP00000217429	kinesin family member 22; Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA	family with sequence similarity 83, member D	0.429
KIF22	KIF4A	ENSP00000160827	ENSP00000363524	kinesin family member 22; Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA	kinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization	0.942
KIF22	UBC	ENSP00000160827	ENSP00000344818	kinesin family member 22; Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA	ubiquitin C	0.919
KIF4A	FAM83D	ENSP00000363524	ENSP00000217429	kinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization	family with sequence similarity 83, member D	0.552
KIF4A	KIF22	ENSP00000363524	ENSP00000160827	kinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization	kinesin family member 22; Kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA	0.942
KIF4A	UBC	ENSP00000363524	ENSP00000344818	kinesin family member 4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization	ubiquitin C	0.752

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